Thèses en cours

• William Pagnoux, . Thèse débutée en 2012. Co-directeur: Emeline Dudognon.
• Ahmed Mourad Salah, Manipulation de l’état physique des matériaux pharmaceutiques amorphes par activation mécanique. Thèse débutée en 2011.
• Aurélien Mahieu, Stabilisation physique des états amorphes par mécanosynthèse d'alliages moléculaires. Thèse débutée en 2010. Co-directeur: Emeline Dudognon.

Thèses soutenues

• Nicolas Dujardin, Amorphisation du glucose à l’état solide et maîtrise de la mutarotation. Thèse soutenue en 2009. Co-directeur: Emeline Dudognon.
• Caron Vincent, Mécanosynthèse d’alliages moléculaires. Thèse soutenue en 2006. Co-directeur: Marc Descamps.
• Armelle De Gusseme, Transformation de phase à l'état solide de matériaux pharmaceutiques: fanansérine et tréhalose. Thèse soutenue en 2003. Co-directeur: Marc Descamps.
• Marlène Tétaert, Etude dynamique de cristaux moléculaires plastiques. Thèse soutenue en 2001. Co-directeur: Marc Descamps.

Communications récentes

7 communication(s) orale(s). 8 communication(s) par affiche. Liste détaillée.

Publications récentes

• 2013
  44. N. Dujardin, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B (2013) [doi: 10.1021/jp3069267]
  43. A. Mahieu, J. f. Willart, E. Dudognon, M. D. Eddleston, W. Jones, F. Danède, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102 pp. 462-468 (2013) [doi: 10.1002/jps.23349]
• 2012
  42. A. Mahieu, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics pp. 121219143735008 (2012) [doi: 10.1021/mp3002254]
  41. J. F. Willart, L. Carpentier, F. Danède, M. Descamps, Solid-state vitrification of crystalline griseofulvin by mechanical milling, Journal of Pharmaceutical Sciences 101 pp. 1570-1577 (2012) [doi: 10.1002/jps.23041]
  40. O. Syll, B. Richard, J. F. Willart, M. Descamps, P. Schuck, G. Delaplace, R. Jeantet, Rehydration behaviour and ageing of dairy powders assessed by calorimetric measurements, Innovative Food Science & Emerging Technologies 14 pp. 139-145 (2012) [doi: 10.1016/j.ifset.2012.01.001]
• 2011
  39. V. Caron, J. F. Willart, R. Lefort, P. Derollez, F. Danède, M. Descamps, Solid state amorphization kinetic of alpha lactose upon mechanical milling, Carbohydrate Research 346 pp. 2622-2628 (2011) [doi: 10.1016/j.carres.2011.09.004]
  38. N. Tabary, A. Mahieu, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, M. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate Research 346 pp. 2193-2199 (2011) [doi: 10.1016/j.carres.2011.07.010]
  37. F. Kreye, F. Siepmann, A. Zimmer, J. F. Willart, M. Descamps, J. Siepmann, Controlled release implants based on cast lipid blends, Europeean Journal of Pharmaceutical Sciences 43 pp. 78 (2011) [doi: 10.1016/j.ejps.2011.03.013]
  36. F. Kreye, F. Siepmann, J. F. Willart, M. Descamps, J. Siepmann, Drug release mechanisms of cast lipid implants, European Journal of Pharmaceutics and Biopharmaceutics 78 pp. 394-400 (2011) [doi: 10.1016/j.ejpb.2011.02.011]
  35. N. Dujardin, E. Dudognon, J. F. Willart, A. Hédoux, Y. Guinet, L. Paccou, M. Descamps, , Solid state mutarotation of glucose, J. Phys. Chem. B 115 pp. 1698-1705 (2011) [doi: 10.1021/jp109382j]
  34. F. Kreye, F. Siepmann, A. Zimmer, J. F. Willart, M. Descamps, J. Siepmann, Cast lipid implants for controlled drug delivery: Importance of the tempering conditions, Journal of Pharmaceutical Sciences 100 pp. 3471-3481 (2011) [doi: 10.1002/jps.22574]
• 2010
  33. J. F. Willart, N. Dujardin, E. Dudognon, F. Danède, M. Descamps, Amorphization of sugar hydrates upon milling , Carbohydrate Research 345 pp. 1613 (2010) [doi: 10.1016/j.carres.2010.04.014]
  32. N. Dujardin, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99 pp. 1476 - 1483 (2010) [doi: 10.1002/jps.21900]
  31. D. Klose, F. Siepmann, J. F. Willart, M. Descamps, J. Siepmann, Drug release from PLGA-based microparticles: Effects of the "microparticle / bulk fluid" ratio, Journal of Pharmaceutics 383 pp. 123-131 (2010) [doi: 10.1016/j.ijpharm.2009.09.012]
• 2009
  30. A. Hédoux, L. Paccou, Y. Guinet, J. F. Willart, M. Descamps, Using the low-frequency Raman spectroscopy to analyze the crystallization of amorphous indomethacin, European Journal of Pharmaceutical Sciences 38 pp. 156 – 164 (2009) [doi: doi:10.1016/j.ejps.2009.06.007]
  29. A. Hédoux, J. F. Willart, L. Paccou, Y. Guinet, F. Affouard, A. Lerbret, M. Descamps, Thermostabilization mechanism of bovine serum albumine by trehalose , Journal of Physical Chemistry B 113 pp. 6119 (2009) [doi: 10.1021/jp900330r]
• 2008
  28. A. D. Gusseme, C. Neves, J. F. Willart, A. Rameau, M. Descamps, Ordering and disordering of molecular solids upon mechanical milling: the case of fananserine , Journal of Pharmaceutical Sciences 97 pp. 5000-5012 (2008) [doi: 10.1002/jps.21472]
  27. N. Dujardin, J. F. Willart, E. Dudognon, A. Hédoux, Y. Guinet, L. Paccou, B. Chazallon, M. Descamps, Solid state vitrification of crystalline a and b-D-glucose by mechanical milling , Solid State Communications 148 pp. 78-82 (2008) [doi: 10.1016/j.ssc.2008.07.002]
  26. J. F. Willart, M. Descamps, Solid state amorphization of pharmaceuticals , Molecular Pharmaceutics 5 pp. 905 (2008) [doi: 10.1021/mp800092t]
  25. J. F. Willart, M. Descamps, V. Caron, Direct crystal to glass transformations of trehalose induced by milling, dehydration and annealing , AIP Conference Proceedings 982 pp. 108-113 (2008) [doi: 10.1063/1.2897763]
• 2007
  24. V. Caron, J. F. Willart, F. Danède, M. Descamps, The implication of the glass transition in the formation of trehalose/mannitol molecular alloys by ball milling , Solid State Communications 144 pp. 288-292 (2007) [doi: 10.1016/j.ssc.2007.09.006]
  23. M. Descamps, J. F. Willart, E. Dudognon, V. Caron, Transformation of pharmaceutical compounds upon milling and comilling: The role of Tg , Journal of Pharmaceutical Sciences 96 pp. 1398-1407 (2007) [doi: 10.1002/jps.20939]
  22. T. P. Shakhtshneider, F. Danède, F. Capet, J. F. Willart, M. Descamps, S. A. Myz, E. V. Boldyreva, V. V. Boldyrev, Grinding of drugs with pharmaceutical excipients at cryogenic temperatures : PPPart I. Cryogenic grinding of piroxicam-polyvinylpyrrolidone mixtures , Journal of Thermal Analysis and Calorimetry 89 pp. 699-707 (2007) [doi: 10.1007/s10973-006-7958-7]
  21. T. P. Shakhtshneider, F. Danède, F. Capet, J. F. Willart, M. Descamps, L. Paccou, E. V. Surov, E. V. Boldyreva, V. V. Boldyrev, Grinding of drugs with pharmaceutical excipients at cryogenic temperatures : PPPart II. Cryogenic grinding of indomethacin-polyvinylpyrrolidone mixtures , Journal of Thermal Analysis and Calorimetry 89 pp. 709-715 (2007) [doi: 10.1007/s10973-006-7959-6]
  20. T. P. Shakhtshneider, F. Danède, F. Capet, J. F. Willart, M. Descamps, S. A. Myz, A. S. Medvedeva, V. V. Boldyrev., Effect of cryogenic grinding on physical-chemical properties of piroxicam and its mixtures with polyvinylpyrrolidone , Chemistry for Sustainable Development (in Russian) 15 pp. 201 (2007)
  19. T. P. Shakhtshneider, F. Danède, F. Capet, J. F. Willart, M. Descamps, E. V. Surov, E. V. Boldyreva, V. V. Boldyrev., Cryogenic grinding of indometacin with polyvinylpyrrolidone , Chemistry for Sustainable Development (in Russian) 15 pp. 209 (2007)
  18. J. F. Willart, V. Caron, M. Descamps, Transformations of crystalline sugars upon milling , Journal of Thermal Analysis and Calorimetry 90 pp. 125-130 (2007) [doi: 10.1007/s10973-007-8485-x]
• 2006
  17. M. Descamps, J. F. Willart, E. Dudognon, Non Equilibrium Transformations of Molecular Compounds Induced Mechanically , AIP Conference Proceedings 832 pp. 56 (2006) [doi: 10.1063/1.2204463]
  16. M. Descamps, J. F. Willart, E. Dudognon, R. Lefort, S. Desprez, V. Caron, Phase transformations induced by grinding: What is revealed by molecular materials , Materials Research Society Symposium Proceedings 979E pp. 116-131, 0979-HH06-06 (2006)
  15. E. Dudognon, J. F. Willart, V. Caron, F. Capet, T. Larsson, M. Descamps, Formation of budesonide/a-lactose glass solutions by ball-milling , Solid State Communications 138 pp. 68-71 (2006) [doi: 10.1016/j.ssc.2006.02.007]
  14. A. Hédoux, R. Ionov, J. F. Willart, A. Lerbret, F. Affouard, Y. Guinet, M. Descamps, D. Prévost, L. Paccou, F. Danède, Evidence of a two-stage thermal denaturation process in lysozyme: a Raman scattering and differential scanning calorimetry investigation , Journal of Chemical Physics 124 pp. 014703-014710 (2006) [doi: 10.1063/1.2139087]
  13. A. Hédoux, J. F. Willart, R. Ionov, F. Affouard, Y. Guinet, L. Paccou, A. Lerbret, M. Descamps, Analysis of sugar bioprotective mechanisms on the thermal denaturation of lysozyme from Raman scattering and differential scanning calorimetry investigations , Journal of Physical Chemistry B 110 pp. 22886-22893 (2006) [doi: 10.1021/jp061568i]
  12. R. Lefort, V. Caron, J. F. Willart, M. Descamps, Mutarotational kinetics and glass transition of lactose , Solid State Communications 140 pp. 329-334 (2006) [doi: 10.1016/j.ssc.2006.09.003]
  11. C. Platteau, J. Lefebvre, S. Hemon, F. Affouard, J. F. Willart, P. Derollez, Ab initio structure determination of two anhydrous forms of α-lactose by powder X-ray diffraction , Zeitschrift fur Kristallographie Supplements 2006 pp. 595-600 (2006) [doi: 10.1524/zksu.2006.suppl_23.595]
  10. J. F. Willart, N. Descamps, V. Caron, F. Capet, F. Danède, M. Descamps, Formation of lactose-mannitol molecular alloys by solid state vitrification , Solid State Communications 138 pp. 194-199 (2006) [doi: 10.1016/j.ssc.2006.02.034]
  9. J. F. Willart, E. Dudognon, N. Descamps, T. Larsson, M. Descamps, Lactose-based molecular alloys obtained by solid state vitrification , Journal of Non-Crystalline Solids 352 pp. 4475-4479 (2006) [doi: 10.1016/j.jnoncrysol.2006.01.142]
  8. J. F. Willart, A. Hédoux, Y. Guinet, F. Danède, L. Paccou, F. Capet, M. Descamps, Metastability release of the alpha form of trehalose by isothermal solid state vitrification , Journal of Physical Chemistry B 110 pp. 11040-11043 (2006) [doi: 10.1021/jp061784r]
• 2005
  7. M. Descamps, J. F. Willart, S. Desprez, Transformation of pharmaceutical compounds by mechanical activation. , Proceedings of an International Conference on Solid-Solid Phase Transformations in Inorganic Materials 1 pp. 835 (2005)
  6. J. Lefebvre, J. F. Willart, V. Caron, R. Lefort, F. Affouard, F. Danède, Structure determination of the 1/1 alpha/beta mixed lactose by powder X-ray diffraction , Acta Crystallographica Section B 61 pp. 455-463 (2005) [doi: 10.1107/S0108768105017064]
  5. C. Platteau, J. Lefebvre, F. Affouard, J. F. Willart, P. Derollez, F. Mallet, Structure determination of the stable anhydrous phase of a-lactose from X-ray powder diffraction , Acta Crystallographica Section B 61 pp. 185 (2005) [doi: 10.1107/S0108768105000455 ]
  4. J. F. Willart, J. Lefebvre, F. Danède, S. Comini, P. Looten, M. Descamps, Polymorphic transformation of the G-form of D-sorbitol upon milling : structural and nanostructural analyses. , Solid State Communications 135 pp. 519 (2005) [doi: 10.1016/j.ssc.2005.04.048]
• 2004
  3. M. Descamps, J. F. Willart, Glassy crystals: above and below Tg , AIP CONFERENCE PROCEEDINGS 708 pp. 591-593 (2004) [doi: 10.1063/1.1764230]
  2. R. Lefort, A. D. Gusseme, J. E. Willart, F. Danede, M. Descamps, Solid state NMR and DSC methods for quantifying the amorphous content in solid dosage forms: an application to ball-milling of trehalose , International Journal of Pharmaceutics 280 pp. 209-219 (2004) [doi: 10.1016/j.ijpharm.2004.05.012]
  1. J. F. Willart, V. Caron, R. Lefort, F. Danede, D. Prevost, M. Descamps, Athermal character of the solid state amorphization of lactose induced by ball milling , Solid State Communications 132 pp. 693-696 (2004) [doi: 10.1016/j.ssc.2004.09.007]