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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

 
Jean-François WILLART
Directeur de recherche CNRS
Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Courriel Envoyer un mel à  Jean-François WILLART: Envoyer un mel à Jean-François WILLART
Identifiant ORCID 0000-0002-7911-3918
: 0000-0002-7911-3918

Recherche

Thème général : Etude des propriétés physiques des matériaux moléculaires hors équilibre: verres et transition vitreuse, métastabilité, cinétiques de transformations de phases. Thème spécifique actuel : amorphisation et transformations polymorphiques à l’état solide induites par broyage mécanique. Applications aux matériaux thérapeutiques et aux problématiques de la formulation pharmaceutique.

Thèses soutenues

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. L.-A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel., International Journal of Pharmaceutics: X 6, 100220 (2024), [doi: 10.1016/j.ijpx.2023.100220, LillOA]
  2. A. Krupa, F. Danede, D. Majda, A. Węgrzyn, D. Strojewski, I. Kondera, J.-F. willart, High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics 188, 137-146 (2023), [doi: 10.1016/j.ejpb.2023.05.014, LillOA]
  3. S. Wachowiak, F. Danede, J.-F. willart, F. Siepmann, J. Siepmann, M. Hamoudi, PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry, Journal of Drug Delivery Science and Technology 86, 104648 (2023), [doi: 10.1016/j.jddst.2023.104648, LillOA]
  4. M. Latreche, J.-F. willart, Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System, Pharmaceutics 15;5, 1505 (2023), [doi: 10.3390/pharmaceutics15051505, LillOA]
  5. C. Henaff, J. Siepmann, F. Siepmann, F. Danede, M.-N. Avettand-Fènoël, J. VERIN, A. Fadel, J.-F. willart, Exploration of the physical states of riboflavin (free base) by mechanical milling, International journal of pharmaceutics 645, 123416 (2023), [doi: 10.1016/j.ijpharm.2023.123416, LillOA]
  6. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. VERIN, C. Vincent, J.-F. willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
  7. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. VERIN, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
  8. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
  9. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
  10. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
  11. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
  12. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
  13. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
  14. A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.-F. willart, P.-E. Lemesre, C. Vincent, J. Siepmann, F. Siepmann, Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”, International Journal of Pharmaceutics: X 100088 (2021), [doi: 10.1016/j.ijpx.2021.100088, LillOA]
  15. O. Cantin, F. Siepmann, J.-F. willart, F. Danede, J. Siepmann, y. karrout, PEO hot melt extrudates for controlled drug delivery: Importance of the type of drug and loading, Journal of Drug Delivery Science and Technology 102238 (2020), [doi: 10.1016/j.jddst.2020.102238, LillOA]
  16. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  17. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
  18. F. Ngono, G.J. Cuello, M. Jimenez-Ruiz, J.-F. willart, M. Guerain, A.R. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics 17, 10-20 (2020), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
  19. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  20. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  21. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. D. Strojewski, S. Lalik, F. Danede, M. Marzec, J.-F. Willart, A. Krupa, Design of co-amorphous fixed-dose combinations of bosentan and sildenafil base, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Mar 2024 [LillOA]
  2. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, 19. Amorphous chlorhexidine (free base) dissolves less rapidly compared to crystalline, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Mar 2024 [LillOA]
  3. Y. Bedulho Das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Mar 2024 [LillOA]
  4. J.-F. Willart, Characterization of amorphous systems by calorimetry, Séminaire invité, Conférence Invitée – Astra Zeneca Suède, Göteborg, France, Mar 2024 [LillOA]
  5. J.-F. Willart, Amorphous Solid Dispersions : Interest, production and stability, Séminaire invité, Séminaire de recherche de l'entreprise Roquette, Lestrem, Mar 2024 [LillOA]
  6. J.-F. Willart, Apport de la DSC à modulation de température pour l'étude des matériaux pharmaceutiques amorphes, Séminaire invité, Journée des utilisateurs TA Instruments, Paris, France, Mar 2024 [LillOA]
  7. J.-F. Willart, Mechanical milling: A useful tool to determine the solubility curve of drugs into polymers, Conférence invitée, Mini-Symposium on Amorphous Solid Dispersions, Louvain (Université Catholique ), Mar 2024 [LillOA]
  8. p. Bordet, P. Martinetto, P. Martinetto, J.-F. Willart, M. Descamps, E. Dudognon, In-situ powder diffraction study of molecular compounds under high energy milling: from amorphization to solid state transformation, Communication dans un congrès sans actes, EPDIC 16 (16th European Powder Diffraction Conference), Edinburgh, Scotland, Mar 2024 [LillOA]
  9. J.-F. Willart, p. Bordet, M. Descamps, E. Dudognon, P. Martinetto, W. Pagnoux, Kinetics of polymorphic transformations of pharmaceuticals induced by mechanical milling, Communication dans un congrès sans actes, ISMANAM 2018 (25th international Symposium on Metastable, Amorphous and Nanostructured Materials), Rome, Mar 2024 [LillOA]
  10. p. Bordet, P. Martinetto, W. Pagnoux, J.-F. Willart, M. Descamps, E. Dudognon, Etude in-situ de composés moléculaires sous broyage à haute énergie: de l'amorphisation à la transformation à l'état solide, Communication dans un congrès sans actes, AFC 2018 (16th European Powder Diffraction Conference), Lyon, Mar 2024 [LillOA]

Liste complète (Le lien peut être lent)

 

Brevets (ancienne liste, avant 2018)

  1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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