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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

HEDOUX Alain
Alain HEDOUX
Professeur
Bâtiment P5 - 253
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 46 77
Fax: +33 (0)3 20 43 40 84
Courriel: alain.hedoux@univ-lille.fr

Recherche

Analyse de l’organisation structurale et de la dynamique des matériaux moléculaires formateurs de verre dans leurs états amorphes et cristallins, des mécanismes de transformation de phases, et de stabilisation d’états amorphes de matériaux d’intérêt thérapeutique (petites molécules, protéines) par des excipients. Analyses par spectroscopie Raman, diffusion des neutrons, RX, calorimétrie.

Enseignement

IUT A – département Mesures Physique : Mécanique du point, du solide indéformable, déformable (élasticité) Master : Organisation structurale des états condensés de la matière.

Thèses soutenues

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. M. Latreche, J. Willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  2. M. Latreche, J. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  3. M. Latreche, J. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]
  4. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen, Microporous and Mesoporous Materials 277, 203-207 (2019), [doi: 10.1016/j.micromeso.2018.10.022, LillOA]
  5. T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International journal of pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
  6. S. Nasser, A. Hedoux, A. Giuliani, C. Le Floch-Fouéré, V. Santé-Lhoutellier, I. De Waele, G. Delaplace, Investigation of secondary structure evolution of micellar casein powder upon aging by FTIR and SRCD: consequences on solubility, Journal of the science of food and agriculture 98, 2243-2250 (2018), [doi: 10.1002/jsfa.8711, LillOA]
  7. y. karrout, F. Siepmann, Y. Benzine, L. Paccou, Y. Guinet, A. Hedoux, J. Siepmann, When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS, International journal of pharmaceutics 539, 39-49 (2018), [doi: 10.1016/j.ijpharm.2018.01.014, LillOA]
  8. S. Nasser, R. Jeantet, P. De-Sa-Peixoto, G. Ronse, N. Nuns, F. Pourpoint, J. Burgain, C. Gaiani, A. Hedoux, G. Delaplace, Microstructure evolution of micellar casein powder upon ageing: Consequences on rehydration dynamics, Journal of Food Engineering 206, 57-66 (2017), [doi: 10.1016/j.jfoodeng.2017.03.004, LillOA]
  9. S. Nasser, A. Moreau, R. Jeantet, A. Hedoux, G. Delaplace, Influence of storage conditions on the functional properties of micellar casein powder, Food and Bioproducts Processing 106, 181-192 (2017), [LillOA]
  10. T. Starciuc, Y. Guinet, L. Paccou, A. Hedoux, Influence of a Small Amount of Glycerol on the Trehalose Bioprotective Action Analyzed In Situ During Freeze-Drying of Lyzozyme Formulations by Micro-Raman Spectroscopy, Journal of Pharmaceutical Sciences 106, 2988-2997 (2017), [doi: 10.1016/j.xphs.2017.05.040, LillOA]
  11. S. Nasser, R. Jeantet, P. Peres De Sa Peixoto Jr, G. Ronse, N. Nuns, F. Pourpoint, J. Burgain, C. Gaiani, A. Hedoux, G. Delaplace, Microstructure evolution of micellar casein powder upon ageing: Consequences on rehydration dynamics, Journal of Food Engineering 206, 57-66 (2017), [doi: 10.1016/j.jfoodeng.2017.03.004, LillOA]
  12. A. Frontzek (neé Svanidze), J. Embs, L. Paccou, Y. Guinet, A. Hedoux, Low-Frequency Dynamics of BSA Complementarily Studied by Raman and Inelastic Neutron Spectroscopy, The Journal of Physical Chemistry B (2017), [doi: 10.1021/acs.jpcb.7b01395, LillOA]
  13. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder, International journal of pharmaceutics (2017), [doi: 10.1016/j.ijpharm.2017.04.067, LillOA]
  14. A. Hedoux, Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, S. Brandán, Structural and vibrational characterization of sugar arabinitol structures employing micro-Raman spectra and DFT calculations, Journal of Molecular Structure 1138, 118-128 (2017), [doi: 10.1016/j.molstruc.2017.03.015, LillOA]
  15. Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, A. Hedoux, Analysis of stochastic crystallization in micron-sized droplets of undercooled liquid l-arabitol, Carbohydrate research 435, 76-82 (2016), [doi: 10.1016/j.carres.2016.09.012, LillOA]
  16. Y. Guinet, L. Paccou, F. Danede, J. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  17. A. Hedoux, Recent developments in the Raman and infrared investigations of amorphous pharmaceuticals and protein formulations: A review, Advanced Drug Delivery Reviews 100, 133-146 (2016), [doi: 10.1016/j.addr.2015.11.021, LillOA]
  18. L. Paccou, Y. Guinet, A. Hedoux, A. Frontzek, Study of the phase transition in lysozyme crystals by Raman spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects 1860, 412-423 (2016), [doi: 10.1016/j.bbagen.2015.10.020, LillOA]
  19. A. Hedoux, L. Paccou, P. Derollez, Y. Guinet, Dehydration mechanism of caffeine hydrate and structural description of driven metastable anhydrates analyzed by micro Raman spectroscopy, International journal of pharmaceutics 486, 331-338 (2015), [doi: 10.1016/j.ijpharm.2015.04.001, LillOA]
  20. A. Hedoux, Y. Guinet, P. Derollez, E. Dudognon, N. T. Correia, Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II, International Journal of Pharmaceutics 421, 45-52 (2011), [doi: 10.1016/j.ijpharm.2011.09.015, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. M. Guerain, P. Derollez, C. Dejoie, N. T. Correia, F. Danede, F. Affouard, L. Paccou, Y. Guinet, A. Hedoux, C. Dejoie, Analyse structurale de matériaux moléculaires thérapeutiques cocristallisés par diffraction des rayons X, Communication dans un congrès sans actes, Rayons X et Matière 2019, Nancy, France, Nov 2019 [LillOA]
  2. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  3. M. Latreche, J. willart, A. Hedoux, Efficient solid state transformation protocol to determine the solubility of drugs into polymers, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  4. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of pharmaceutical materials within mesoporous silica matrices, Communication dans un congrès sans actes, 1st International Conference on Contemporary Pharmacy Challenges: 1st International Conference on Contemporary Pharmacy Challenges:, Wisla, Pologne, Sep 2018 [LillOA]
  5. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Mechanism of protein stabilization analyzed from in-situ Raman investigations during freeze-drying procedures, Conférence invitée, Freeze-drying of pharmaceuticals & biologicals, Garmisch-Partenkirchen, Allemagne, Sep 2018 [LillOA]
  6. T. Starciuc, A. Hedoux, Y. Guinet, L. Paccou, Mechanisms of protein denaturation and stabilization analyzed in-situ during the freeze-drying process by micro-Raman spectroscopy, Conférence invitée, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Juil 2017 [LillOA]
  7. B. Malfait, N. T. Correia, A. Mussi, Y. Guinet, A. Hedoux, Confinement of APIs inside porous silicate matrices by milling: analysis of the physical state and stability of confined APIs, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Grenade, Espagne, Mar 2018 [LillOA]
  8. J. Junthip, N. Tabary, B. Martel, N. Blanchemain, F. Chai, M. Maton, C. Neut, A. Hedoux, D. Landy, Multilayer assembly of oppositely charged cyclodextrin polymers on textile for controlled drug delivery, Communication dans un congrès sans actes, Pure and Applied Chemistry International Conference (PACCON), Bangkok, Thaïlande, Fév 2016 [LillOA]
  9. J. Junthip, N. Tabary, B. Martel, N. Blanchemain, F. Chai, A. Hedoux, D. Landy, L. Leclercq, Dual cyclodextrin polyelectrolyte multilayer coatings on textile for controlled drug delivery, Communication dans un congrès sans actes, EuroCD2015, Lille, France, Oct 2015 [LillOA]
  10. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, The solvent dynamical transition is a necessary precursor to promote the protein unfolding, Communication dans un congrès sans actes, International Symposium On the Properties of Water, ISOPOW XIII, Lausanne, Suisse, Juin 2016 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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