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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

AFFOUARD Frédéric
Frédéric AFFOUARD
Professeur Directeur Adjoint du Laboratoire
Bâtiment P5 - 221
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 68 15
Fax: +33 (0)3 20 43 40 84
Courriel: frederic.affouard@univ-lille.fr

Recherche

Compréhension des mécanismes physiques de la transition vitreuse de matériaux moléculaires composés de petites molécules organiques (cristaux vitreux, liquides). Optimisation de la stabilité des biomolécules. Simulation de dynamique moléculaire. Diffusion neutronique.

Enseignement

Enseignements au Département de Physique de la Faculté des Sciences:- L1: mécaniques, pression, ondes- Master1: "Structure et dynamique des matériaux", "Outils numériques pour la physique".- Master2: "Transformations de phases", "Modélisation".Enseignements à l'IUT A "Mesures Physiques" Capteurs.

Thèses en cours

Thèses soutenues

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. F. Ngono, G. Cuello, M. Jimenez-Ruiz, J. willart, M. Guerain, A. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics (2019), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
  2. E. Dudognon, F. Affouard, J. Bama, Molecular Mobility of Terfenadine: Investigation by Dielectric Relaxation Spectroscopy and Molecular Dynamics Simulation, Molecular Pharmaceutics 16;11, 4711-4724 (2019), [doi: 10.1021/acs.molpharmaceut.9b00877, LillOA]
  3. F. Ngono, J. willart, G. Cuello, M. Jimenez-Ruiz, C. Hamoudi-Ben Yelles, F. Affouard, Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose, Molecular Pharmaceutics (2019), [doi: 10.1021/acs.molpharmaceut.9b00740, LillOA]
  4. J. Gerges, F. Affouard, Insight from molecular dynamics simulations on the crystallization tendency of indomethacin polymorphs in the undercooled liquid state, Journal of Pharmaceutical Sciences (2019), [doi: 10.1016/j.xphs.2019.10.054, LillOA]
  5. L. Roca Paixao, N. T. Correia, F. Affouard, Affinity prediction computations and mechanosynthesis of carbamazepine based cocrystals, Crystengcomm (2019), [doi: 10.1039/c9ce01160a, LillOA]
  6. F. Ngono Mebenga, J. willart, G. Cuello, M. Jimenez-Ruiz, F. Affouard, Lactulose: a model system to investigate solid state amorphization induced by milling, Journal of Pharmaceutical Sciences 108, 880-887 (2019), [doi: 10.1016/j.xphs.2018.09.013, LillOA]
  7. B. Atawa, N. T. Correia, N. Couvrat, F. Affouard, G. Coquerel, E. Dargent, A. Saiter, Molecular Mobility of Amorphous N-Acetyl-α-Methylbenzylamine and Debye Relaxation evidenced by Dielectric Relaxation Spectroscopy and Molecular Dynamic Simulations, Physical Chemistry Chemical Physics 21, 702 - 717 (2019), [doi: 10.1039/C8CP04880K, LillOA]
  8. M. Ottou Abe, M. Viciosa, N. T. Correia, F. Affouard, Impact of chirality on peculiar ibuprofen molecular dynamics: hydrogen bonding organization and syn vs. anti carboxylic group conformations, Physical Chemistry Chemical Physics 20, 29528-29538 (2018), [doi: 10.1039/C8CP04837A, LillOA]
  9. A. Bourdet, A. Esposito, S. Thiyagarajan, L. Delbreilh, F. Affouard, R. Knoop, E. Dargent, Molecular Mobility in Amorphous Biobased Poly(ethylene 2,5-furandicarboxylate) and Poly(ethylene 2,4-furandicarboxylate), Macromolecules 51, 1937-1945 (2018), [doi: 10.1021/acs.macromol.8b00108, LillOA]
  10. L. Valdes, J. Gerges, T. Mizuguchi, F. Affouard, Crystallization tendencies of modelled Lennard-Jones liquids with different attractions, The Journal of Chemical Physics 148, 14501 (2018), [doi: 10.1063/1.5004659, LillOA]
  11. K. Koperwas, F. Affouard, J. Gerges, K. Adrjanowicz, L. Valdes, M. Paluch, Influence of pressure on the crystallization of systems characterized by different intermolecular attraction, Physical Review B 96, (2017), [doi: 10.1103/PhysRevB.96.224106, LillOA]
  12. A. Lerbret, F. Affouard, Molecular Packing, Hydrogen Bonding, and Fast Dynamics in Lysozyme/Trehalose/Glycerol and Trehalose/Glycerol Glasses at Low Hydration, The Journal of Physical Chemistry B 121, 9437-9451 (2017), [doi: 10.1021/acs.jpcb.7b07082, LillOA]
  13. M. Ottou Abe, N. T. Correia, J. Ndjaka, F. Affouard, A comparative study of ibuprofen and ketoprofen glass-forming liquids by molecular dynamics simulations, The Journal of Chemical Physics 143, 164506 (2015), [doi: 10.1063/1.4933430, LillOA]
  14. J. Gerges, F. Affouard, Predictive Calculation of the Crystallization Tendency of Model Pharmaceuticals in the Supercooled State from Molecular Dynamics Simulations, The Journal of Physical Chemistry B 119, 10768-10783 (2015), [doi: 10.1021/acs.jpcb.5b05557, LillOA]
  15. M. Ottou Abe, N. T. Correia, L. Valdes, J. Ndjaka, F. Affouard, Local molecular organizations of ibuprofen, flurbiprofen and ketoprofen in the liquid phase: Insights from molecular dynamics simulations, Journal of Molecular Liquids 205, 74 (2015), [doi: 10.1016/j.molliq.2014.08.015, LillOA]
  16. A. Brás, I. Fonseca, M. Dionísio, A. Schönhals, F. Affouard, N. T. Correia, Influence of Nanoscale Confinement on the Molecular Mobility of Ibuprofen, The Journal of Physical Chemistry C 140527133525002 (2014), [doi: 10.1021/jp500630m, LillOA]
  17. A. Rodrigues, M. Viciosa, F. Danede, F. Affouard, N. T. Correia, Molecular Mobility of AmorphousS-Flurbiprofen: A Dielectric Relaxation Spectroscopy Approach, Molecular Pharmaceutics 11, 112 (2014), [doi: 10.1021/mp4002188, LillOA]
  18. L. Duponchel, S. Laurette, B. Hatirnaz, A. Treizebre, f. affouard, B. Bocquet, Terahertz microfluidic sensor for in situ exploration of hydration shell of molecules, Chemometrics and Intelligent Laboratory Systems 123, 28-35 (2013), [doi: 10.1016/j.chemolab.2013.01.009, LillOA]
  19. F. Affouard, M. Ottou Abe, L. Valdes, N. T. Correia, Role of pre-peaks in glass-forming liquids, AIP Conference Proceedings 121-127 (2013), [doi: 10.1063/1.4794558, LillOA]
  20. S. Laurette, A. Treizebre, A. Elagli, B. Hatirnaz, R. Froidevaux, F. Affouard, L. Duponchel, B. Bocquet, Highly sensitive terahertz spectroscopy in microsystem, RSC Advances 2, 10064 (2012), [doi: 10.1039/c2ra21320f, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. M. Guerain, P. Derollez, C. Dejoie, N. T. Correia, F. Danede, F. Affouard, L. Paccou, Y. Guinet, A. Hedoux, C. Dejoie, Analyse structurale de matériaux moléculaires thérapeutiques cocristallisés par diffraction des rayons X, Communication dans un congrès sans actes, Rayons X et Matière 2019, Nancy, France, Nov 2019 [LillOA]
  2. L. Roca Paixao, F. Affouard, N. T. Correia, Carbamazepin cocrystals revisited, Communication dans un congrès sans actes, BIOFIT MARSEILLE - INTERREG 2 Seas IMODE Project Fourth annual convention, Marseille, France, Déc 2019 [LillOA]
  3. J. Bama, E. Dudognon, F. Affouard, Investigation of complex molecular dynamics in multi-component systems, Communication dans un congrès sans actes, BIOFIT MARSEILLE - INTERREG 2 Seas IMODE Project Fourth annual convention, Marseille, France, Déc 2019 [LillOA]
  4. J. Bama, E. Dudognon, F. Affouard, Investigation of amorphous solid solution of pharmaceutical interest obtained by grinding, Poster, 17th European Conference on Solid Sate Chemistry (ECSSC17), Villeneuve d'Ascq, France, Sep 2019 [LillOA]
  5. F. Affouard, Contribution of MD simulations for the understanding of the structural, dynamical and thermodynamical properties of molecular liquids, Communication dans un congrès sans actes, Atelier sur les Solvants Eutectiques Profonds organisé par le GDR SolvATE, Rennes, France, Oct 2019 [LillOA]
  6. J. Bama, E. Dudognon, F. Affouard, CARACTERISATION D’UN MELANGE PHARMACEUTIQUE PRINCIPE ACTIF-EXCIPIENT POLYMERE, Communication dans un congrès sans actes, 50ème Journées de Calorimétrie et d’Analyse Thermique, Saint-Valéry en Caux, France, Juin 2019 [LillOA]
  7. L. Roca Paixao, F. Ngono Mebenga, J. willart, G. Cuello, M. Jimenez-Ruiz, N. T. Correia, F. Affouard, Manipulation of the crystalline and amorphous physical states of pharmaceutical materials: possibilities, limits and challenges, Conférence invitée, 32nd European Crystallographic Meeting (ECM32), Vienna, Autriche, Aou 2019 [LillOA]
  8. F. Affouard, Investigation of pharmaceutical amorphous materials obtained by different amorphization processes: Interplay between chemical and physical modifications, Conférence invitée, 4th International Symposium on Metastable Materials Science & Technology, Qinhuangdao, Chine, Oct 2019 [LillOA]
  9. F. Ngono Mebenga, F. Affouard, J. willart, G. Cuello, M. Jimenez-Ruiz, Impact of the amorphisation routes on physical properties of amorphous materials, Communication dans un congrès sans actes, Journées de la Matière Condensée (JMC 2018), Grenoble, France, Aou 2018 [LillOA]
  10. B. Atawa, N. Couvrat, G. Coquerel, E. Dargent, N. T. Correia, F. Affouard, A. Saiter, Molecular mobility of chiral amorphous compounds: Original case study of Nac-MBA, Communication dans un congrès sans actes, 10th Conference on Broadband Dielectric spectroscopy and its applications, Brussels, Belgique, Aou 2018 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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