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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

 
Jean-François WILLART
Chercheur CNRS
Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Courriel: Jean-Francois.Willart@univ-lille.fr

Recherche

Thème général : Etude des propriétés physiques des matériaux moléculaires hors équilibre: verres et transition vitreuse, métastabilité, cinétiques de transformations de phases. Thème spécifique actuel : amorphisation et transformations polymorphiques à l’état solide induites par broyage mécanique. Applications aux matériaux thérapeutiques et aux problématiques de la formulation pharmaceutique.

Thèses en cours

Thèses soutenues

Brevets

  1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. F. Ngono Mebenga, J. willart, G. Cuello, M. Jimenez-Ruiz, F. Affouard, Lactulose: a model system to investigate solid state amorphization induced by milling, Journal of Pharmaceutical Sciences 108, 880-887 (2019), [doi: 10.1016/j.xphs.2018.09.013, LillOA]
  2. P. Oliveira, J. willart, J. Siepmann, F. Siepmann, M. Descamps, Using Milling To Explore Physical States: The Amorphous and Polymorphic Forms of Dexamethasone, Crystal Growth & Design 18, 1748-1757 (2018), [doi: 10.1021/acs.cgd.7b01664, LillOA]
  3. M. Descamps, J. willart, Scaling laws and size effects for amorphous crystallization kinetics: Constraints imposed by nucleation and growth specificities, International journal of pharmaceutics 542, 186-195 (2018), [doi: 10.1016/j.ijpharm.2018.03.001, LillOA]
  4. A. Mahieu, J. willart, M. Guerain, P. Derollez, F. Danede, M. Descamps, Structure determination of phase II of the antifungal drug griseofulvin by powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 74, 321-324 (2018), [doi: 10.1107/S2053229618001845, LillOA]
  5. E. Elisei, J. willart, F. Danede, J. Siepmann, F. Siepmann, M. Descamps, Crystalline Polymorphism Emerging From a Milling-Induced Amorphous Form: The Case of Chlorhexidine Dihydrochloride, Journal of Pharmaceutical Sciences 107, 121-126 (2018), [doi: 10.1016/j.xphs.2017.07.003, LillOA]
  6. M. Hamoudi-Ben Yelles, V. Tran Tan, F. Danede, J. willart, J. Siepmann, PLGA implants: How Poloxamer/PEO addition slows down or accelerates polymer degradation and drug release, Journal of controlled release 253, 19-29 (2017), [doi: 10.1016/j.jconrel.2017.03.009, LillOA]
  7. H. Gasmi, F. Siepmann, M. Hamoudi, F. Danede, J. Verin, J. willart, J. Siepmann, Towards a better understanding of the different release phases from PLGA microparticles: Dexamethasone-loaded systems, International journal of pharmaceutics 514, 189-199 (2016), [doi: 10.1016/j.ijpharm.2016.08.032, LillOA]
  8. O. Cantin, F. Siepmann, F. Danede, J. willart, y. karrout, J. Siepmann, PEO hot melt extrudates for controlled drug delivery: Importance of the molecular weight, Journal of Drug Delivery Science and Technology 36, 130-140 (2016), [doi: 10.1016/j.jddst.2016.09.003, LillOA]
  9. M. Gehrke, J. Sircoglou, D. Gnansia, G. Tourrel, J. willart, F. Danede, E. Lacante, C. Vincent, F. Siepmann, J. Siepmann, Ear Cubes for local controlled drug delivery to the inner ear, International journal of pharmaceutics 509, 85-94 (2016), [doi: 10.1016/j.ijpharm.2016.04.003, LillOA]
  10. A. Krupa, M. Descamps, J. willart, B. Strach, E. Wyska, R. Jachowicz, F. Danede, High-Energy Ball Milling as Green Process To Vitrify Tadalafil and Improve Bioavailability, Molecular Pharmaceutics 13, 3891-3902 (2016), [doi: 10.1021/acs.molpharmaceut.6b00688, LillOA]
  11. A. Krupa, M. Descamps, J. willart, R. Jachowicz, F. Danede, High energy ball milling and supercritical carbon dioxide impregnation as co-processing methods to improve dissolution of tadalafil, European Journal of Pharmaceutical Sciences 95, 130-137 (2016), [doi: 10.1016/j.ejps.2016.05.007, LillOA]
  12. Y. Guinet, L. Paccou, F. Danede, J. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  13. M. Descamps, A. Aumelas, S. Desprez, J. willart, The amorphous state of pharmaceuticals obtained or transformed by milling: Sub-Tg features and rejuvenation, Journal of Non-Crystalline Solids 407, 72-80 (2015), [doi: 10.1016/j.jnoncrysol.2014.08.055, LillOA]
  14. H. Gasmi, J. willart, F. Danede, M. Hamoudi, J. Siepmann, F. Siepmann, Importance of PLGA microparticle swelling for the control of prilocaine release, Journal of Drug Delivery Science and Technology 30, 123-132 (2015), [doi: 10.1016/j.jddst.2015.10.009, LillOA]
  15. M. Nieto-Bobadilla, F. Siepmann, M. Djouina, L. Dubuquoy, N. Tesse, J. willart, L. Dubreuil, J. Siepmann, C. Neut, Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance, European journal of pharmaceutics and biopharmaceutics 96, 152-161 (2015), [doi: 10.1016/j.ejpb.2015.07.012, LillOA]
  16. A. Vynckier, H. Lin, J. Zeitler, J. willart, E. Bongaers, J. Voorspoels, J. Remon, C. Vervaet, Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion, European journal of pharmaceutics and biopharmaceutics 96, 125-131 (2015), [doi: 10.1016/j.ejpb.2015.07.023, LillOA]
  17. Y. Jallouli, J. willart, F. Siepmann, M. Descamps, F. Danede, J. Siepmann, Preparation of polymeric fenofibrate formulations with accelerated drug release: Solvent evaporation versus co-grinding, Journal of Drug Delivery Science and Technology 30, 397-407 (2015), [doi: 10.1016/j.jddst.2015.07.013, LillOA]
  18. E. Elisei, M. Filibian, P. Carretta, S. Colombo Serra, F. Tedoldi, J. willart, M. Descamps, A. Cesàro, Dynamic nuclear polarization of a glassy matrix prepared by solid state mechanochemical amorphization of crystalline substances, Chemical Communications 51, 2080-2083 (2015), [doi: 10.1039/C4CC08348B, LillOA]
  19. E. Gué, S. MUSCHERT, J. willart, F. Danede, M. Descamps, E. Delcourt-Debruyne, J. Siepmann, Accelerated fenofibrate release from spray-dried microparticles based on polymer blends, Journal of Drug Delivery Science and Technology 24, 185-190 (2014), [doi: 10.1016/S1773-2247(14)50030-5, LillOA]
  20. E. Gue, S. MUSCHERT, J. willart, F. Danede, E. Delcourt-Debruyne, M. Descamps, J. Siepmann, Accelerated ketoprofen release from spray-dried polymeric particles: importance of phase transitions and excipient distribution, Drug development and industrial pharmacy 41, 838-850 (2014), [doi: 10.3109/03639045.2014.908902, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. F. Tamani, C. Bassand, M. Yelles, J. willart, F. Danede, F. Siepmann, J. Siepmann, How single PLGA microparticles behave, Poster, 3rd European Conference on Pharmaceutics, Bologne, Italie, Mar 2018 [LillOA]
  2. M. Garcia-Fernandez, N. Tabary, F. Chai, J. willart, N. Blanchemain, M. Flament, B. Martel, Cyclodextrin polymer as a multifunctional excipient in tablet formulations, Poster, 19th International Cyclodextrin Symposium (ICS 2018)., Tokyo, Japon, Avr 2018 [LillOA]
  3. T. Rongthong, M. Gehrke, P. Oliveira, F. Danede, J. willart, C. Vincent, F. Siepmann, J. Siepmann, Silicone matrices for controlled drug delivery to the inner ear: Effects of the drug form and agglomerates, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  4. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  5. M. Garcia Fernandez, N. Tabary, J. willart, F. Chai, N. Blanchemain, M. Leterme Flament, B. Martel, 2.Multifunctional pharmaceutical excipient in tablet formulation based on citric acid-cyclodextrin polymer, Poster, 5th European Cyclodextrin Conference (EUROCD 2017), Lisbonne, Portugal, Oct 2017 [LillOA]
  6. M. Garcia Fernandez, N. Tabary, J. willart, F. Chai, N. Blanchemain, M. Leterme Flament, B. Martel, New pharmaceutical excipient based on polymers of cyclodextrins, Poster, 18ème Journées de la société française des cyclodextrines, Lens, France, Nov 2017 [LillOA]
  7. A. Krupa, M. Descamps, J. willart, F. Danede, E. Wyska, R. Jachowicz, The technological solutions to enhance the bioavailability of tadalafil, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  8. M. Latreche, J. willart, A. Hedoux, Efficient solid state transformation protocol to determine the solubility of drugs into polymers, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  9. F. Ngono Mebenga, F. Affouard, J. willart, G. Cuello, M. Jimenez-Ruiz, Impact of the amorphisation routes on physical properties of amorphous materials, Communication dans un congrès sans actes, Journées de la Matière Condensée (JMC 2018), Grenoble, France, Aou 2018 [LillOA]
  10. F. Ngono Mebenga, F. Affouard, J. willart, Physico-chemical properties of amorphous lactulose: role of water, Communication dans un congrès sans actes, 1res Journées Scientifiques du GDR 2035 SolvATE, Nancy, France, Mai 2018 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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