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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

PACCOU Laurent
Laurent PACCOU
Ingénieur d'étude
Bâtiment P5 - 241
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 43 35/+33 (0)3 20 43 49 96
Fax: +33 (0)3 20 43 40 84
Courriel: laurent.paccou@univ-lille.fr

Activité

Analyse de l’organisation structurale et de la dynamique des matériaux moléculaires formateurs de verre dans leurs états amorphes et cristallins, des mécanismes de transformation de phases, et de stabilisation d’états amorphes de matériaux d’intérêt thérapeutique (petites molécules, protéines) par des excipients. Analyses par spectroscopie Raman, diffusion des neutrons, RX, calorimétrie

Enseignement

IUT A – département Mesures Physique : Vacataire, TP Logique Combinatoire (52h/an), Multiplexeur, Bascule RS, JK, D Cours (8h/an) et TD (22h/an) Technique du Vide, Calcul d’installations, les unités légales, le libre parcours moyen, section efficace de collision, les différents régimes d’écoulement, Nombre de Reynolds et Nombre de Knusden. HEI – Interrogateur Orale en Classe Préparatoire 1er Année en Physique 56h/an

Responsabilité d'instruments

micro Spectromètre Raman Renishaw InVia, adapté aux études à moyennes fréquences (150-1800 cm-1, Microcalorimètre MicroDSC7 evo (Setaram), Spectromètre Raman XY Dilor, adapté aux études Macro à Basses fréquences (5-500 cm-1)

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen, Microporous and Mesoporous Materials 277, 203-207 (2019), [doi: 10.1016/j.micromeso.2018.10.022, LillOA]
  2. T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International journal of pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
  3. y. karrout, F. Siepmann, Y. Benzine, L. Paccou, Y. Guinet, A. Hedoux, J. Siepmann, When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS, International journal of pharmaceutics 539, 39-49 (2018), [doi: 10.1016/j.ijpharm.2018.01.014, LillOA]
  4. T. Starciuc, Y. Guinet, L. Paccou, A. Hedoux, Influence of a Small Amount of Glycerol on the Trehalose Bioprotective Action Analyzed In Situ During Freeze-Drying of Lyzozyme Formulations by Micro-Raman Spectroscopy, Journal of Pharmaceutical Sciences 106, 2988-2997 (2017), [doi: 10.1016/j.xphs.2017.05.040, LillOA]
  5. A. Frontzek (neé Svanidze), J. Embs, L. Paccou, Y. Guinet, A. Hedoux, Low-Frequency Dynamics of BSA Complementarily Studied by Raman and Inelastic Neutron Spectroscopy, The Journal of Physical Chemistry B (2017), [doi: 10.1021/acs.jpcb.7b01395, LillOA]
  6. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder, International journal of pharmaceutics (2017), [doi: 10.1016/j.ijpharm.2017.04.067, LillOA]
  7. A. Hedoux, Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, S. Brandán, Structural and vibrational characterization of sugar arabinitol structures employing micro-Raman spectra and DFT calculations, Journal of Molecular Structure 1138, 118-128 (2017), [doi: 10.1016/j.molstruc.2017.03.015, LillOA]
  8. Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, A. Hedoux, Analysis of stochastic crystallization in micron-sized droplets of undercooled liquid l-arabitol, Carbohydrate research 435, 76-82 (2016), [doi: 10.1016/j.carres.2016.09.012, LillOA]
  9. Y. Guinet, L. Paccou, F. Danede, J. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  10. J. Junthip, N. Tabary, F. Chai, L. Leclercq, M. Maton, F. Cazaux, C. Neut, L. Paccou, Y. Guinet, J. STAELENS, M. Bria, D. Landy, A. Hedoux, N. Blanchemain, B. Martel, Layer by layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery, Journal of Biomedical Materials Research Part A 104, 1408-1424 (2016), [doi: 10.1002/jbm.a.35674, LillOA]
  11. L. Paccou, Y. Guinet, A. Hedoux, A. Frontzek, Study of the phase transition in lysozyme crystals by Raman spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects 1860, 412-423 (2016), [doi: 10.1016/j.bbagen.2015.10.020, LillOA]
  12. A. Hedoux, L. Paccou, P. Derollez, Y. Guinet, Dehydration mechanism of caffeine hydrate and structural description of driven metastable anhydrates analyzed by micro Raman spectroscopy, International journal of pharmaceutics 486, 331-338 (2015), [doi: 10.1016/j.ijpharm.2015.04.001, LillOA]
  13. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, How Does Glycerol Enhance the Bioprotective Properties of Trehalose? Insight from Protein-Solvent Dynamics, The Journal of Physical Chemistry B 118, 8928-8934 (2014), [doi: 10.1021/jp500673b, LillOA]
  14. A. Hedoux, L. Paccou, Y. Guinet, Relationship between β-relaxation and structural stability of lysozyme: Microscopic insight on thermostabilization mechanism by trehalose from Raman spectroscopy experiments, The Journal of Chemical Physics 140, 225102 (2014), [doi: 10.1063/1.4882058, LillOA]
  15. A. Hedoux, Y. Guinet, L. Paccou, P. Derollez, F. Danede, Vibrational and structural properties of amorphous n-butanol: A complementary Raman spectroscopy and X-ray diffraction study, The Journal of Chemical Physics 138, 214506 (2013), [doi: 10.1063/1.4808159, LillOA]
  16. G. Bellavia, L. Paccou, S. Achir, Y. Guinet, J. Siepmann, A. Hedoux, Analysis of Bulk and Hydration Water During Thermal Lysozyme Denaturation Using Raman Scattering, Food Biophysics 8, 170-176 (2013), [doi: 10.1007/s11483-013-9294-3, LillOA]
  17. A. Hedoux, L. Paccou, S. Achir, Y. Guinet, Mechanism of protein stabilization by trehalose during freeze-drying analyzed by in situ micro-raman spectroscopy, Journal of Pharmaceutical Sciences 102, 2484-2494 (2013), [doi: 10.1002/jps.23638, LillOA]
  18. P. Derollez, A. Hedoux, Y. Guinet, F. Danede, L. Paccou, Structure determination of the crystalline phase ofn-butanol by powder X-ray diffraction and study of intermolecular associations by Raman spectroscopy, Acta Crystallographica Section B Structural Science Crystal Engineering and Materials 69, 195-202 (2013), [doi: 10.1107/S0108768113004849, LillOA]
  19. A. Hedoux, Y. Guinet, L. Paccou, F. Danede, P. Derollez, Polymorphic transformation of anhydrous caffeine upon grinding and hydrostatic pressurizing analyzed by low-frequency raman spectroscopy, Journal of Pharmaceutical Sciences 102, 162-170 (2013), [doi: 10.1002/jps.23346, LillOA]
  20. P. Blanpain Avet, A. Hedoux, Y. Guinet, L. Paccou, J. Petit, T. Six, G. Delaplace, Analysis by Raman spectroscopy of the conformational structure of whey proteins constituting fouling deposits during the processing in a heat exchanger, Journal of Food Engineering 110, 86-94 (2012), [doi: 10.1016/j.jfoodeng.2011.12.005, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  2. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of pharmaceutical materials within mesoporous silica matrices, Communication dans un congrès sans actes, 1st International Conference on Contemporary Pharmacy Challenges: 1st International Conference on Contemporary Pharmacy Challenges:, Wisla, Pologne, Sep 2018 [LillOA]
  3. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Mechanism of protein stabilization analyzed from in-situ Raman investigations during freeze-drying procedures, Conférence invitée, Freeze-drying of pharmaceuticals & biologicals, Garmisch-Partenkirchen, Allemagne, Sep 2018 [LillOA]
  4. T. Starciuc, A. Hedoux, Y. Guinet, L. Paccou, Mechanisms of protein denaturation and stabilization analyzed in-situ during the freeze-drying process by micro-Raman spectroscopy, Conférence invitée, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Juil 2017 [LillOA]
  5. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Protein denaturation and stabilization during freeze-drying analyzed from in-situ micro Raman investigations, Conférence invitée, International Symposium On the Properties of Water, ISOPOW XIII, Lausanne, Suisse, Juin 2016 [LillOA]
  6. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, The solvent dynamical transition is a necessary precursor to promote the protein unfolding, Communication dans un congrès sans actes, International Symposium On the Properties of Water, ISOPOW XIII, Lausanne, Suisse, Juin 2016 [LillOA]
  7. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, Role of glycerol on trehalose to enhance biostability in relation with fast anharmonic and quasi-harmonic motions, Communication dans un congrès sans actes, ProtStab2014 : 10th International Conference on Protein Stabilisation, Stresa, Italie, Mai 2014 [LillOA]
  8. A. Hedoux, L. Paccou, Y. Guinet, The contribution of the low-frequency Raman spectroscopy to the structural description of disordered molecular systems and their transformations: application to pharmaceuticals, Conférence invitée, SciX 2015, Providence (Rhode Island), Etats-Unis d'Amérique, Oct 2015 [LillOA]
  9. A. Hedoux, L. Paccou, Y. Guinet, Solid state transformations of APIs induced by various stresses analyzed in real time by Raman spectroscopy, Conférence invitée, AMPTEC, Lille, France, Juil 2014 [LillOA]
  10. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Micro-Raman Spectroscopy used as a PAT tool and for real time monitoring of protein stability during freeze drying, Communication dans un congrès sans actes, SciX 2015, Providence (Rhode Island), Etats-Unis d'Amérique, Sep 2015 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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