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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

GUINET Yannick
Yannick GUINET
Professeur
Bâtiment P5bis - 251
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 33 63 91
Fax: +33 (0)3 20 43 40 84
Courriel: Yannick.Guinet@univ-lille.fr

Recherche

Analyse par spectroscopie RAMAN des mécanismes de transformation de phases,et de stabilisation d’états amorphes de matériaux d’intérêt thérapeutique (petites molécules, protéines) par des excipients.

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. B. Malfait, N.T. Correia, C. Ciotonea, J. Dhainaut, J.-P. Dacquin, S. Royer, N. Tabary, Y. Guinet, A. Hédoux, Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree, The Journal of Chemical Physics 153;15, 154506 (2020), [doi: 10.1063/5.0020992, LillOA]
  2. B. Malfait, N. T. Correia, C. Ciotonea, J. Dhainaut, J.-P. Dacquin, s. royer, N. Tabary, Y. Guinet, A. Hedoux, Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree, The Journal of Chemical Physics 153;15, 154506 (2020), [doi: 10.1063/5.0020992, LillOA]
  3. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  4. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
  5. T. Starciuc, B. Malfait, F. Danede, L. Paccou, Y. Guinet, N. T. Correia, A. Hedoux, Trehalose or sucrose; which of the two should be used for stabilizing proteins in the solid state? A dilemma investigated by in-situ micro-Raman and dielectric relaxation spectroscopies during and after freeze-drying, Journal of Pharmaceutical Sciences 109;1, 496-504 (2019), [doi: 10.1016/j.xphs.2019.10.055, LillOA]
  6. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  7. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen, Microporous and Mesoporous Materials 277, 203-207 (2019), [doi: 10.1016/j.micromeso.2018.10.022, LillOA]
  8. T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International journal of pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
  9. y. karrout, F. Siepmann, Y. Benzine, L. Paccou, Y. Guinet, A. Hedoux, J. Siepmann, When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS, International journal of pharmaceutics 539, 39-49 (2018), [doi: 10.1016/j.ijpharm.2018.01.014, LillOA]
  10. T. Starciuc, Y. Guinet, L. Paccou, A. Hedoux, Influence of a Small Amount of Glycerol on the Trehalose Bioprotective Action Analyzed In Situ During Freeze-Drying of Lyzozyme Formulations by Micro-Raman Spectroscopy, Journal of Pharmaceutical Sciences 106, 2988-2997 (2017), [doi: 10.1016/j.xphs.2017.05.040, LillOA]
  11. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder, International journal of pharmaceutics (2017), [doi: 10.1016/j.ijpharm.2017.04.067, LillOA]
  12. A.V. Frontzek (neé Svanidze), J.P. Embs, L. Paccou, Y. Guinet, A. Hedoux, Low-Frequency Dynamics of BSA Complementarily Studied by Raman and Inelastic Neutron Spectroscopy, The Journal of Physical Chemistry B (2017), [doi: 10.1021/acs.jpcb.7b01395, LillOA]
  13. A. Hedoux, Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, S.A. Brandán, Structural and vibrational characterization of sugar arabinitol structures employing micro-Raman spectra and DFT calculations, Journal of Molecular Structure 1138, 118-128 (2017), [doi: 10.1016/j.molstruc.2017.03.015, LillOA]
  14. Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, A. Hedoux, Analysis of stochastic crystallization in micron-sized droplets of undercooled liquid l-arabitol, Carbohydrate research 435, 76-82 (2016), [doi: 10.1016/j.carres.2016.09.012, LillOA]
  15. Y. Guinet, L. Paccou, F. Danede, J. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  16. L. Paccou, Y. Guinet, A. Hedoux, A. Frontzek, Study of the phase transition in lysozyme crystals by Raman spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects 1860, 412-423 (2016), [doi: 10.1016/j.bbagen.2015.10.020, LillOA]
  17. A. Hedoux, L. Paccou, P. Derollez, Y. Guinet, Dehydration mechanism of caffeine hydrate and structural description of driven metastable anhydrates analyzed by micro Raman spectroscopy, International journal of pharmaceutics 486, 331-338 (2015), [doi: 10.1016/j.ijpharm.2015.04.001, LillOA]
  18. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, How Does Glycerol Enhance the Bioprotective Properties of Trehalose? Insight from Protein-Solvent Dynamics, The Journal of Physical Chemistry B 118, 8928-8934 (2014), [doi: 10.1021/jp500673b, LillOA]
  19. A. Hedoux, L. Paccou, Y. Guinet, Relationship between β-relaxation and structural stability of lysozyme: Microscopic insight on thermostabilization mechanism by trehalose from Raman spectroscopy experiments, The Journal of Chemical Physics 140, 225102 (2014), [doi: 10.1063/1.4882058, LillOA]
  20. P. Blanpain Avet, A. Hedoux, Y. Guinet, L. Paccou, J. Petit, T. Six, G. Delaplace, Analysis by Raman spectroscopy of the conformational structure of whey proteins constituting fouling deposits during the processing in a heat exchanger, Journal of Food Engineering 110, 86-94 (2012), [doi: 10.1016/j.jfoodeng.2011.12.005, LillOA]
  21. A. Hedoux, Y. Guinet, P. Derollez, E. Dudognon, N. T. Correia, Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II, International Journal of Pharmaceutics 421, 45-52 (2011), [doi: 10.1016/j.ijpharm.2011.09.015, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. M. Guerain, P. Derollez, C. Dejoie, N. T. Correia, F. Danede, F. Affouard, L. Paccou, Y. Guinet, A. Hedoux, C. Dejoie, Analyse structurale de matériaux moléculaires thérapeutiques cocristallisés par diffraction des rayons X, Communication dans un congrès sans actes, Rayons X et Matière 2019, Nancy, France, Nov 2019 [LillOA]
  2. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  3. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of pharmaceutical materials within mesoporous silica matrices, Communication dans un congrès sans actes, 1st International Conference on Contemporary Pharmacy Challenges: 1st International Conference on Contemporary Pharmacy Challenges:, Wisla, Pologne, Sep 2018 [LillOA]
  4. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Mechanism of protein stabilization analyzed from in-situ Raman investigations during freeze-drying procedures, Conférence invitée, Freeze-drying of pharmaceuticals & biologicals, Garmisch-Partenkirchen, Allemagne, Sep 2018 [LillOA]
  5. T. Starciuc, A. Hedoux, Y. Guinet, L. Paccou, Mechanisms of protein denaturation and stabilization analyzed in-situ during the freeze-drying process by micro-Raman spectroscopy, Conférence invitée, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Juil 2017 [LillOA]
  6. B. Malfait, N. T. Correia, A. Mussi, Y. Guinet, A. Hedoux, Confinement of APIs inside porous silicate matrices by milling: analysis of the physical state and stability of confined APIs, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Grenade, Espagne, Mar 2018 [LillOA]
  7. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Protein denaturation and stabilization during freeze-drying analyzed from in-situ micro Raman investigations, Conférence invitée, International Symposium On the Properties of Water, ISOPOW XIII, Lausanne, Suisse, Juin 2016 [LillOA]
  8. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, The solvent dynamical transition is a necessary precursor to promote the protein unfolding, Communication dans un congrès sans actes, International Symposium On the Properties of Water, ISOPOW XIII, Lausanne, Suisse, Juin 2016 [LillOA]
  9. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, Role of glycerol on trehalose to enhance biostability in relation with fast anharmonic and quasi-harmonic motions, Communication dans un congrès sans actes, ProtStab2014 : 10th International Conference on Protein Stabilisation, Stresa, Italie, Mai 2014 [LillOA]
  10. A. Hedoux, L. Paccou, Y. Guinet, The contribution of the low-frequency Raman spectroscopy to the structural description of disordered molecular systems and their transformations: application to pharmaceuticals, Conférence invitée, SciX 2015, Providence (Rhode Island), Etats-Unis d'Amérique, Oct 2015 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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