Bernard MARTEL

Professor

Bâtiment C6, Bureau 119
Unité Matériaux et Transformations
Cité scientifique, Bât. C6
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: 03 20 43 46 35
Fax: +33 (0) 320 43 65 91
Email: bernard.martel@univ-lille.fr

Research team: Ingénierie des systèmes polymères

Research

Functional polymeric systems applied to biomaterials for the release of therapeutic agents

Current PhD thesis

• Bilal ASSAAD, Electrofilage de cyclodextrine pour la conception de nanofibre à propriétés antibactériennes. Thesis started in 2019. Other co-advisor: BAKKOUR Youssef.
• Marie Stella M BENGUE, Conception and evaluation of fenestred endoprothesis by 3D printig . Thesis started in 2019.

Defended PhD thesis

• Dyhia KERSANI, Recouvrement de stent vasculaire par electrospinning pour la prévention de la restérose et de la thrombose . Thesis defended in 2019. Other co-advisor: Stéphanie DEGOUTIN. Present position: Soutenance en décembre 2019.
• Syrine DIMASSI, Antithrombotic or osteoinductive bioactive membranes developed by electrospinning. Thesis defended in 2018. Other co-advisor: Nicolas TABARY.
• Safa Ouerghemmi, Electrospinning of antibacterial and anti-thrombotic chitosan based nanofibrous web. Thesis defended in 2016. Other co-advisors: Stéphanie DEGOUTIN, Nicolas TABARY. Present position: Ingénieur R&D chez Cousin Biotech.
• Jatupol Junthip, Cyclodextrin polyelectrolytes multilayer coatings on textiles for the release of actives. Thesis defended in 2015. Other co-advisor: Nicolas TABARY. Present position: Lecturer, Nakhon Ratchasima Rajabhat University, Thailand.
• Camille Saffre, Eco-design of ion-exchange textiles functionalized with bio-sourced polymers to decontaminate metals in dredged sediments. Thesis defended in 2015. Other co-advisors: Maryse BACQUET, Stéphanie DEGOUTIN. Present position: Chargée de veille et intelligence économique chez Matikem  .
• Adeline Martin, Multilayered textile coating for drug delivery application. Thesis defended in 2013. Other co-advisor: Nicolas TABARY. Present position: Chargée de Mission Santé Innovation - Croissance.
• Guillaume Vermet, Contribution of new antibacterial and analgesic properties on a implant for parietal refection. Thesis defended in 2012. Other co-advisor: Stéphanie DEGOUTIN. Present position: Product Development Project Manager.
• Imen Kacem, Textiles with biological activity via the grafting by cold plasma and the immobilization of bioactive molecules. Thesis defended in 2012. Other co-advisors: Maude JIMENEZ, Roudesli Sadok . Present position: Maître de conférences en Tunisie.
• Hélène Dhordain, Functionalization of nowoven structure by cyclodextrin for the working-out of a biocidal textile filter. Thesis defended in 2011. Present position: Responsable R&D et Laboratoire chez Galloo Plastics SA.
• Tabary Nicolas, Functionalisation of biodegradable cellulose supports for the prolonged release of antibacterial agents for periodontological applications. Thesis defended in 2009. Other co-advisor: Blanchemain Nicolas.
• Laurent Thomas, Bloodproofing, antiseptic treatment and dyeing of a vascular prosthesis finished with cyclodextrin. Thesis defended in 2008. Other co-advisor: Hildebrand H.F..
• Lepretre Stéphane, Functionalisation of porous hydroxyapatite for the sustained delivery of antibiotics. Thesis defended in 2008. Other co-advisors: Blanchemain Nicolas, Hildebrand H.F..
• El Ghoul Yassine, Textile finishing with cyclodextrins of PP and PA supports- Application to dyeing and as antibiotic controlled release biomaterial. Thesis defended in 2007. Other co-advisor: Roudesli Sadok .
• Boschin François, Membrane functionalization for tissular controlled regeneration by controlled release of chlorhexidine in parodontology. Thesis defended in 2006. Other co-advisors: Hildebrand H.F., Delcourt-Debruyne E..
• Ducoroy Laurent, Modification of texilte fibers for the preparation of ion exchange texiles-Application to metallic decontamination of waste waters. Thesis defended in 2006. Other co-advisor: Maryse BACQUET.
• Nicolas Blanchemain, Study of the biocompatibility and of the grafting reaction of cyclodextrins onto PET vascular prostheses for the realization of a drug release device. Thesis defended in 2005. Present position: Inserm U1008 "Médicaments et Biomatériaux à Libération Contrôlée", Faculté de Pharmacie, Université Lille 2.
• Ruffin Delphine , Polymerization and grafting of cyclodextrins onto textile fibers by crosslinking with polycarboxylic acids. Study of the process, and applications. Thesis defended in 2002. Other co-advisor: Michel Morcellet.
• Philippe Le Thuaut, Functionalisation of textile supports for the elaboration of filters for the adsorption of organic pollutants. Thesis defended in 2000. Other co-advisor: Michel Morcellet.

Patents

10. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1
9. 2017 - N. Blanchemain, B. Martel, C. Flores, F. Cazaux, F. Chai, N. Tabary, M. Lopez: Procédé de fabrication d'hydrogel à base de chitosan et de polyélectrolytes chargés négativement et matériau poreux alvéolaire issu dudit hydrogel.
   Brevet français FR3038318 déposé le 02/07/2015 Numéro de publication internationale : WO2017/001808 A1
8. 2012 - B. Martel, Et Al: Dispositif implantable de réparation et de reconstruction osseuse apte à adsorber des agents bio-actifs et procédés de fabrication d’un tel dispositif.
   brevet français FR-12 52690 déposé le 26/03/2012
7. 2011 - B. Martel, Et Al: Dispositif de filtration d’un flux d’air a activite anti-bacterienne et/ou anti-virale et/ou anti-fongique et procede de preparation d’un tel dispositif.
   brevet français n° 11/61887 déposé le 19/12/2011
6. 2010 - B. Martel, N. Tabary, Et Al: Dispositif resorbable permettant la libération prolongée de chlorhexidine dans la poche parodontale.
   brevet n° 1058433 déposé le 15/10/2010
5. 2008 - T. Laurent, B. Martel, M. Morcellet, N. Blanchemain, H. F. Hildebrand: Prothèse vasculaire imperméable et procédé de préparation de ladite prothèse.
   WO 2009/095594
4. 2006 - S. Haulon, J. Mondot, H. F. Hildebrand, N. Blanchemain, B. Martel: Method for preparing an implantable prosthesis from a porous base body and associated prosthesis and use thereof .
   EP2086603 (A2), WO2007FR01822 ; FR20060009678 ; FR20070058629 JP2010508109 (A)
3. 2006 - B. Martel, N. Blanchemain, M. Morcellet, H. F. Hildebrand, S. Haulon, F. Boschin, E. Delcourt-Debruyne: Biomatériaux porteurs de cyclodextrines aux propriétés d’absorption améliorées et de libération progressive et retardée de molécules thérapeutiques.
   FR2 877 846 B1 PCT/FR2005/002829 WO 2006/051227 CN101080247A EP05817573.8 JPN : 2007-540685
2. 2006 - M. Weltrowski, M. Morcellet, B. Martel: Procédé de traitement d’une fibre ou d’un matériau à base de fibres en vue d’améliorer ses propriétés adsorbantes et fibre ou matériau à base de fibres présentant des propriétés adsorbantes améliorées..
   FR 9901967 (2000) DE 600 10 055 T2 (2005) EP 1,157,156 B1 (2004) US 7,048,769B1 (2006) CA 2,362,534 WO 0047811
1. 2003 - B. Martel, M. Morcellet, M. Weltrowski: Procédé de fabrication de polymères solubles et insolubles à base de cyclodextrine(s) et /ou de dérivés de cyclodextrine(s) et polymères solubles à base de cyclodextrine(s) et/ou de dérivés de cyclodextrine(s).
   FR 2 789 685 (2001) EP 1 165 621 B1 (2002) US 6,660,804 B1 (2003) WO 00/047630 (2000)

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

21. C. Palomino-Durand, M. Lopez, P. Marchandise, B. Martel, N. Blanchemain, F. Chai, Chitosan/polycyclodextrin (cht/pcd)-based sponges delivering vegf to enhance angiogenesis for bone regeneration, Pharmaceutics 12, (2020), [doi: 10.3390/pharmaceutics12090784, LillOA]
20. J. Junthip, N. Tabary, M. Maton, S. Ouerghemmi, J.-N. STAELENS, F. Cazaux, C. Neut, N. Blanchemain, B. Martel, Release-killing properties of a textile modified by a layer-by-layer coating based on two oppositely charged cyclodextrin polyelectrolytes, International Journal of Pharmaceutics 587, 119730 (2020), [doi: 10.1016/j.ijpharm.2020.119730, LillOA]
19. S. Fadlallah, N. Tabary, S. Noel, B. Leger, F. Cazaux, E. Monflier, B. Martel, Synthesis of novel catalytic composite nanofibers containing ruthenium nanoparticles stabilized by a citric acid-β-cyclodextrin polymer, Nanoscale Advances 2;5, 2087-2098 (2020), [doi: 10.1039/c9na00791a, LillOA]
18. D. Kersani, J. Mougin, M. Lopez, S. Willai, N. Tabary, F. Cazaux, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Stent coating by electrospinning with chitosan/poly-cyclodextrin based nanofibers loaded with simvastatin for restenosis prevention, European Journal of Pharmaceutics and Biopharmaceutics 150, 156-167 (2020), [doi: 10.1016/j.ejpb.2019.12.017, LillOA]
17. F. Aubert-Viard, A. Mogrovejo-Valdivia, N. Tabary, M. Maton, F. Chai, C. Neut, B. Martel, N. Blanchemain, Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application, Materials science & engineering. C, Materials for biological applications 100, 554-563 (2019), [doi: 10.1016/j.msec.2019.03.044, LillOA]
16. C. Palomino-Durand, M. Lopez, F. Cazaux, B. Martel, N. Blanchemain, F. Chai, Influence of the Soluble Insoluble Ratios of Cyclodextrins Polymers on the Viscoelastic Properties of Injectable Chitosan Based Hydrogels for Biomedical Application, Polymers 11, 214 (2019), [doi: 10.3390/polym11020214, LillOA]
15. A. Mogrovejo-Valdivia, O. Rahmouni, N. Tabary, M. Maton, C. Neut, B. Martel, N. Blanchemain, In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system, International journal of pharmaceutics 556, 301-310 (2019), [doi: 10.1016/j.ijpharm.2018.12.018, LillOA]
14. T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International journal of pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
13. F. Chai, M. Maton, S. Degoutin, G. Vermet, N. Simon, C. Rousseaux, B. Martel, N. Blanchemain, In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine, Biomaterials 192, 260-270 (2019), [doi: 10.1016/j.biomaterials.2018.07.032, LillOA]
12. N. Morin-Crini, S. Loiacono, V. Placet, G. Torri, C. Bradu, M. Kostić, C. Cosentino, G. Chanet, B. Martel, E. Lichtfouse, G. Crini, Hemp-based adsorbents for sequestration of metals: a review, Environmental Chemistry Letters (2018), [doi: 10.1007/s10311-018-0812-x, LillOA]
11. S. Dimassi, N. Tabary, F. Chai, N. Blanchemain, B. Martel, Sulfonated and sulfated chitosan derivatives for biomedical applications: A review, Carbohydrate polymers 202, 382-396 (2018), [doi: 10.1016/j.carbpol.2018.09.011, LillOA]
10. S. Loiacono, N. Morin-Crini, B. Martel, G. Chanet, C. Bradu, G. Torri, G. Crini, Complexation du zinc, du cuivre et du manganèse par du chanvre : efficacité chimique et impact écotoxicologique, Environnement, Risques & Santé 17, 240-252 (2018), [doi: 10.1684/ers.2018.1174, LillOA]
9. S. Ouerghemmi, S. Dimassi, N. Tabary, L. Leclercq, S. Degoutin, F. Chai, C. Pierlot, F. Cazaux, A. Ung, J.-N. STAELENS, N. Blanchemain, B. Martel, Synthesis and characterization of polyampholytic aryl-sulfonated chitosans and their in vitro anticoagulant activity, Carbohydrate polymers 196, 8-17 (2018), [doi: 10.1016/j.carbpol.2018.05.025, LillOA]
8. D.O. De Castro, N. Tabary, B. Martel, A. Gandini, N. Belgacem, J. Bras, Controlled release of carvacrol and curcumin: bio-based food packaging by synergism action of TEMPO-oxidized cellulose nanocrystals and cyclodextrin, Cellulose 25, 1249-1263 (2018), [doi: 10.1007/s10570-017-1646-6, LillOA]
7. C. Flores, M. Lopez, N. Tabary, C. Neut, F. Chai, D. Betbeder, C. Herkt, F. Cazaux, V. Gaucher, B. Martel, N. Blanchemain, Preparation and characterization of novel chitosan and beta-cyclodextrin polymer sponges for wound dressing applications, Carbohydrate polymers 173, 535-546 (2017), [doi: 10.1016/j.carbpol.2017.06.026, LillOA]
6. S. Noel, D. Bourbiaux, N. Tabary, A. Ponchel, B. Martel, E. Monflier, B. Leger, Acid-tolerant cyclodextrin-based ruthenium nanoparticles for the hydrogenation of unsaturated compounds in water, Catalysis Science & Technology 7;24, 5982-5992 (2017), [doi: 10.1039/C7CY01687E, LillOA]
5. C. Flores, S. Degoutin, F. Chai, G. Raoul, J.-C. Hornez, B. Martel, J. Siepmann, J. Ferri, N. Blanchemain, Gentamicin-loaded poly(lactic-co-glycolic acid) microparticles for the prevention of maxillofacial and orthopedic implant infections, Materials Science and Engineering: C 64, 108-116 (2016), [doi: 10.1016/j.msec.2016.03.064, LillOA]
4. A. Pérez-Anes, M. Gargouri, W. Laure, H. Van Den Berghe, E. Courcot, J. Sobocinski, N. Tabary, F. Chai, J.-F. Blach, A. Addad, P. Woisel, D. Douroumis, B. Martel, N. Blanchemain, J. Lyskawa, Bioinspired Titanium Drug Eluting Platforms Based on a Poly-β-cyclodextrin–Chitosan Layer-by-Layer Self-Assembly Targeting Infections, ACS Applied Materials & Interfaces 7;23, 12882-12893 (2015), [doi: 10.1021/acsami.5b02402, LillOA]
3. R. Herbois, S. Noel, B. Leger, S. Tilloy, S. Menuel, A. Addad, B. Martel, A. Ponchel, E. Monflier, Ruthenium-containing β-cyclodextrin polymer globules for the catalytic hydrogenation of biomass-derived furanic compounds, Green Chem. 17, 2444-2454 (2015), [doi: 10.1039/C5GC00005J, LillOA]
2. N. Tabary, A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, m. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate research 346, 2193-2199 (2011), [doi: 10.1016/j.carres.2011.07.010, LillOA]
1. N. Tabary, S. Leprêtre, F. Boschin, N. Blanchemain, C. Neut, E. Delcourt Debruyne, B. Martel, M. Morcellet, H.F. Hildebrand, Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin, Biomolecular Engineering 24, 472-476 (2007), [doi: 10.1016/j.bioeng.2007.07.007, LillOA]

Full list (The link could be slow)

Communications

10. M.-J. Garcia Fernandez, N. Tabary, F. Chai, J. Willart, N. Blanchemain, M.-P. Leterme Flament, B. Martel, Cyclodextrin polymer as a multifunctional excipient in tablet formulations, Poster, 19th International Cyclodextrin Symposium (ICS 2018)., Tokyo, Japon, Apr 2018 [LillOA]
9. D. Kersani, J. Mougin, M. Lopez, S. Degoutin, N. Tabary, F. Cazaux, L. Janus, B. Hue, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Coating of vascular stents with simvastatin loaded nanofibers by electrospinning for the prevention of restenosis and thrombosis, Communication dans un congrès sans actes, ESB 2018, Maastricht, Pays-Bas, Sep 2018 [LillOA]
8. M. Lopez, D. Kersani, J. Mougin, N. Tabary, F. Cazaux, S. Degoutin, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Electrospun polyvinyl alcohol – cyclodextrin nanofibers for biomedical applications, Communication dans un congrès sans actes, ESB 2018, Maastricht, Pays-Bas, Sep 2018 [LillOA]
7. J. Mougin, D. Kersani, A. Hertault, M. Lopez, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, J. Mougin, Simvastatin release from nanofibers covered stent and development of a rabbit iliac model for assessment of anti-restenosis bio-activity, ESB 2018, Communication dans un congrès sans actes, Simvastatin release from nanofibers covered stent and development of a rabbit iliac model for assessment of anti-restenosis bio-activity, ESB 2018, Maastricht, Pays-Bas, Sep 2018 [LillOA]
6. S. Dimassi, N. Tabary, S. Degoutin, F. Cazaux, L. Janus, B. Hue, F. Chai, J.-C. Hornez, N. Blanchemain, B. Martel, Surface functionalization and biomineralization of chitosan-based electrospun nanofibres for bone tissue engineering, Communication dans un congrès sans actes, 2nd BIOMAT Congress, Ambleteuse, France, Jun 2017 [LillOA]
5. D. Kersani, M. Lopez, J. Mougin, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Drug-eluting stents coated with poly-cyclodextrin nanofibres, Communication dans un congrès sans actes, 5th European conference on cyclodextrins, Lisbonne, Portugal, Oct 2017 [LillOA]
4. D. Kersani, M. Lopez, J. Mougin, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Drug-Eluting stents coated with nanofibers using electrospinning, Communication dans un congrès sans actes, 2nd BIOMAT Congress, Ambleteuse, France, Jun 2017 [LillOA]
3. M. Lopez, D. Kersani, J. Mougin, N. Tabary, F. Cazaux, S. Degoutin, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Study on the PVA stability of electrospun fibers for biomedical applications, Communication dans un congrès sans actes, 2nd BIOMAT Congress, Ambleteuse, France, Jun 2017 [LillOA]
2. J. Mougin, D. Kersani, A. Hertault, M. Lopez, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Simvastatin loaded electrospun membrane covered stent for intra-stent restenosis, Communication dans un congrès sans actes, European Symposium of Vascular Biomaterials, Strasbourg, France, Oct 2017 [LillOA]
1. S. Ouerghemmi, S. Degoutin, N. Tabary, F. Cazaux, L. Janus, B. Hue, F. Chai, N. Blanchemain, B. Martel, Monolithic and coaxial antimicrobial electrospun nanofibers based on chitosan and cyclodextrin polymer, Communication dans un congrès sans actes, Monolithic and coaxial antimicrobial electrospun nanofibers based on chitosan and cyclodextrin polymer,5th European conference on cyclodextrins, Lisbonne Portugal, Oct 2017 [LillOA]

Full list (The link could be slow)