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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

 
Jean-François WILLART
CNRS researcher
Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Email: Jean-Francois.Willart@univ-lille.fr

Research

Main theme : Investigation of physical properties of molecular materials in non equilibrium conditions : glasses and glass transition, metastability, kinetics of phases transformations. Current specific theme : Solid state amorphization and polymorphic transformations induced by mechanical milling. Application to therapeutic materials and to the current issues of the pharmaceutical formulation.

Current PhD thesis

Defended PhD thesis

Patents

  1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

  1. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  2. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
  3. F. Ngono, G.J. Cuello, M. Jimenez-Ruiz, J. willart, M. Guerain, A.R. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics 17, 10-20 (2020), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
  4. F. Ngono, J.-F. willart, G.J. Cuello, M. Jimenez-Ruiz, C.-M. Hamoudi-Ben Yelles, F. Affouard, Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose, Molecular Pharmaceutics 17, 1-9 (2020), [doi: 10.1021/acs.molpharmaceut.9b00740, LillOA]
  5. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  6. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  7. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]
  8. F. Tamani, C. Bassand, M. Hamoudi, F. Danede, J.-F. willart, F. Siepmann, J. Siepmann, Mechanistic explanation of the (up to) 3 release phases of PLGA microparticles: Diprophylline dispersions, International Journal of Pharmaceutics 118819 (2019), [doi: 10.1016/j.ijpharm.2019.118819, LillOA]
  9. F. Tamani, M. Hamoudi, F. Danede, J.-F. willart, F. Siepmann, J. Siepmann, Towards a better understanding of the release mechanisms of caffeine from PLGA microparticles, Journal of Applied Polymer Science 48710 (2019), [doi: 10.1002/app.48710, LillOA]
  10. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Hot melt extruded polysaccharide blends for controlled drug delivery, Journal of Drug Delivery Science and Technology 101317 (2019), [doi: 10.1016/j.jddst.2019.101317, LillOA]
  11. F. Ngono Mebenga, J.-F. willart, G.J. Cuello, M. Jimenez-Ruiz, F. Affouard, Lactulose: a model system to investigate solid state amorphization induced by milling, Journal of Pharmaceutical Sciences 108, 880-887 (2019), [doi: 10.1016/j.xphs.2018.09.013, LillOA]
  12. P.F.M. Oliveira, J. willart, J. Siepmann, F. Siepmann, M. Descamps, Using Milling To Explore Physical States: The Amorphous and Polymorphic Forms of Dexamethasone, Crystal Growth & Design 18, 1748-1757 (2018), [doi: 10.1021/acs.cgd.7b01664, LillOA]
  13. P. Martinetto, P. Bordet, M. Descamps, E. Dudognon, W. Pagnoux, J. willart, Structural Transformations of d -Mannitol Induced by in Situ Milling Using Real Time Powder Synchrotron Radiation Diffraction, Crystal Growth & Design 17, 6111-6122 (2017), [doi: 10.1021/acs.cgd.7b01283, LillOA]
  14. J. willart, E. Dudognon, A. Mahieu, M.D. Eddleston, W. Jones, M. Descamps, The role of cracks in the crystal nucleation process of amorphous griseofulvin, The European Physical Journal Special Topics 226, 837-847 (2017), [doi: 10.1140/epjst/e2016-60358-y, LillOA]
  15. P. Bordet, A. Bytchkov, M. Descamps, E. Dudognon, E. Elkaïm, P. Martinetto, W. Pagnoux, A. Poulain, J. willart, Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis, Crystal Growth & Design 16, 4547-4558 (2016), [doi: 10.1021/acs.cgd.6b00660, LillOA]
  16. A. Mahieu, J. willart, E. Dudognon, F. Danede, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics 10, 560-566 (2013), [doi: 10.1021/mp3002254, LillOA]
  17. A. Mahieu, J. willart, E. Dudognon, M.D. Eddleston, W. Jones, F. Danede, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102, 462-468 (2013), [doi: 10.1002/jps.23349, LillOA]
  18. N. Dujardin, J. willart, E. Dudognon, F. Danede, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B 117, 1437-1443 (2013), [doi: 10.1021/jp3069267, LillOA]
  19. N. Tabary, A. Mahieu, J. willart, E. Dudognon, F. Danede, M. Descamps, m. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate research 346, 2193-2199 (2011), [doi: 10.1016/j.carres.2011.07.010, LillOA]
  20. N. Dujardin, E. Dudognon, J. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
  21. N. Dujardin, J. willart, E. Dudognon, F. Danede, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99, 1476 - 1483 (2010), [doi: 10.1002/jps.21900, LillOA]

Full list (The link could be slow)

Communications

  1. L.-V. Roca Paixao, F. Ngono Mebenga, J.-F. willart, G.J. Cuello, M. Jimenez-Ruiz, N. T. Correia, F. Affouard, Manipulation of the crystalline and amorphous physical states of pharmaceutical materials: possibilities, limits and challenges, Conférence invitée, 32nd European Crystallographic Meeting (ECM32), Vienna, Autriche, Aug 2019 [LillOA]
  2. F. Tamani, C. Bassand, M.H.-B. Yelles, J. willart, F. Danede, F. Siepmann, J. Siepmann, How single PLGA microparticles behave, Poster, 3rd European Conference on Pharmaceutics, Bologne, Italie, Mar 2018 [LillOA]
  3. M.-J. Garcia Fernandez, N. Tabary, F. Chai, J. willart, N. Blanchemain, M.-P. Leterme Flament, B. Martel, Cyclodextrin polymer as a multifunctional excipient in tablet formulations, Poster, 19th International Cyclodextrin Symposium (ICS 2018)., Tokyo, Japon, Apr 2018 [LillOA]
  4. T. Rongthong, M. Gehrke, P. Oliveira, F. Danede, J. willart, C. Vincent, F. Siepmann, J. Siepmann, Silicone matrices for controlled drug delivery to the inner ear: Effects of the drug form and agglomerates, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  5. M.J. Garcia Fernandez, N. Tabary, J. willart, F. Chai, N. Blanchemain, M.P. Leterme Flament, B. Martel, 2.Multifunctional pharmaceutical excipient in tablet formulation based on citric acid-cyclodextrin polymer, Poster, 5th European Cyclodextrin Conference (EUROCD 2017), Lisbonne, Portugal, Oct 2017 [LillOA]
  6. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  7. M.J. Garcia Fernandez, N. Tabary, J. willart, F. Chai, N. Blanchemain, M.P. Leterme Flament, B. Martel, New pharmaceutical excipient based on polymers of cyclodextrins, Poster, 18ème Journées de la société française des cyclodextrines, Lens, France, Nov 2017 [LillOA]
  8. A. Krupa, M. Descamps, J. willart, F. Danede, E. Wyska, R. Jachowicz, The technological solutions to enhance the bioavailability of tadalafil, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  9. M. Latreche, J. willart, A. Hedoux, Efficient solid state transformation protocol to determine the solubility of drugs into polymers, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  10. F. Ngono Mebenga, F. Affouard, J. willart, G. Cuello, M. Jimenez-Ruiz, Impact of the amorphisation routes on physical properties of amorphous materials, Communication dans un congrès sans actes, Journées de la Matière Condensée (JMC 2018), Grenoble, France, Aug 2018 [LillOA]

Full list (The link could be slow)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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