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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

HEDOUX Alain
Alain HEDOUX
Professeur
Bâtiment P5 - 253
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 46 77
Fax: +33 (0)3 20 43 40 84
Courriel: alain.hedoux@univ-lille.fr

Recherche

Analyse de l’organisation structurale et de la dynamique des matériaux moléculaires formateurs de verre dans leurs états amorphes et cristallins, des mécanismes de transformation de phases, et de stabilisation d’états amorphes de matériaux d’intérêt thérapeutique (petites molécules, protéines) par des excipients. Analyses par spectroscopie Raman, diffusion des neutrons, RX, calorimétrie.

Enseignement

IUT A – département Mesures Physique : Mécanique du point, du solide indéformable, déformable (élasticité) Master : Organisation structurale des états condensés de la matière.

Thèses en cours

Thèses soutenues

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen, Microporous and Mesoporous Materials 277, 203-207 (2019), [doi: 10.1016/j.micromeso.2018.10.022, LillOA]
  2. T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International journal of pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
  3. S. Nasser, A. Hedoux, A. Giuliani, C. Le Floch-Fouéré, V. Santé-Lhoutellier, I. De Waele, G. Delaplace, Investigation of secondary structure evolution of micellar casein powder upon aging by FTIR and SRCD: consequences on solubility, Journal of the science of food and agriculture 98, 2243-2250 (2018), [doi: 10.1002/jsfa.8711, LillOA]
  4. y. karrout, F. Siepmann, Y. Benzine, L. Paccou, Y. Guinet, A. Hedoux, J. Siepmann, When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS, International journal of pharmaceutics 539, 39-49 (2018), [doi: 10.1016/j.ijpharm.2018.01.014, LillOA]
  5. S. Nasser, A. Moreau, R. Jeantet, A. Hedoux, G. Delaplace, Influence of storage conditions on the functional properties of micellar casein powder, Food and Bioproducts Processing 106, 181-192 (2017), [LillOA]
  6. T. Starciuc, Y. Guinet, L. Paccou, A. Hedoux, Influence of a Small Amount of Glycerol on the Trehalose Bioprotective Action Analyzed In Situ During Freeze-Drying of Lyzozyme Formulations by Micro-Raman Spectroscopy, Journal of Pharmaceutical Sciences 106, 2988-2997 (2017), [doi: 10.1016/j.xphs.2017.05.040, LillOA]
  7. S. Nasser, R. Jeantet, P. Peres De Sa Peixoto Jr, G. Ronse, N. Nuns, F. Pourpoint, J. Burgain, C. Gaiani, A. Hedoux, G. Delaplace, Microstructure evolution of micellar casein powder upon ageing: Consequences on rehydration dynamics, Journal of Food Engineering 206, 57-66 (2017), [doi: 10.1016/j.jfoodeng.2017.03.004, LillOA]
  8. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder, International journal of pharmaceutics (2017), [doi: 10.1016/j.ijpharm.2017.04.067, LillOA]
  9. A. Frontzek (neé Svanidze), J. Embs, L. Paccou, Y. Guinet, A. Hedoux, Low-Frequency Dynamics of BSA Complementarily Studied by Raman and Inelastic Neutron Spectroscopy, The Journal of Physical Chemistry B (2017), [doi: 10.1021/acs.jpcb.7b01395, LillOA]
  10. A. Hedoux, Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, S. Brandán, Structural and vibrational characterization of sugar arabinitol structures employing micro-Raman spectra and DFT calculations, Journal of Molecular Structure 1138, 118-128 (2017), [doi: 10.1016/j.molstruc.2017.03.015, LillOA]
  11. Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, A. Hedoux, Analysis of stochastic crystallization in micron-sized droplets of undercooled liquid l-arabitol, Carbohydrate research 435, 76-82 (2016), [doi: 10.1016/j.carres.2016.09.012, LillOA]
  12. Y. Guinet, L. Paccou, F. Danede, J. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  13. A. Hedoux, Recent developments in the Raman and infrared investigations of amorphous pharmaceuticals and protein formulations: A review, Advanced Drug Delivery Reviews 100, 133-146 (2016), [doi: 10.1016/j.addr.2015.11.021, LillOA]
  14. J. Junthip, N. Tabary, F. Chai, L. Leclercq, M. Maton, F. Cazaux, C. Neut, L. Paccou, Y. Guinet, J. STAELENS, M. Bria, D. Landy, A. Hedoux, N. Blanchemain, B. Martel, Layer by layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery, Journal of Biomedical Materials Research Part A 104, 1408-1424 (2016), [doi: 10.1002/jbm.a.35674, LillOA]
  15. L. Paccou, Y. Guinet, A. Hedoux, A. Frontzek, Study of the phase transition in lysozyme crystals by Raman spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects 1860, 412-423 (2016), [doi: 10.1016/j.bbagen.2015.10.020, LillOA]
  16. A. Hedoux, L. Paccou, P. Derollez, Y. Guinet, Dehydration mechanism of caffeine hydrate and structural description of driven metastable anhydrates analyzed by micro Raman spectroscopy, International journal of pharmaceutics 486, 331-338 (2015), [doi: 10.1016/j.ijpharm.2015.04.001, LillOA]
  17. A. Hedoux, L. Paccou, Y. Guinet, Relationship between β-relaxation and structural stability of lysozyme: Microscopic insight on thermostabilization mechanism by trehalose from Raman spectroscopy experiments, The Journal of Chemical Physics 140, 225102 (2014), [doi: 10.1063/1.4882058, LillOA]
  18. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, How Does Glycerol Enhance the Bioprotective Properties of Trehalose? Insight from Protein-Solvent Dynamics, The Journal of Physical Chemistry B 118, 8928-8934 (2014), [doi: 10.1021/jp500673b, LillOA]
  19. A. Hedoux, Y. Guinet, L. Paccou, P. Derollez, F. Danede, Vibrational and structural properties of amorphous n-butanol: A complementary Raman spectroscopy and X-ray diffraction study, The Journal of Chemical Physics 138, 214506 (2013), [doi: 10.1063/1.4808159, LillOA]
  20. G. Bellavia, L. Paccou, S. Achir, Y. Guinet, J. Siepmann, A. Hedoux, Analysis of Bulk and Hydration Water During Thermal Lysozyme Denaturation Using Raman Scattering, Food Biophysics 8, 170-176 (2013), [doi: 10.1007/s11483-013-9294-3, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. T. Starciuc, N. T. Correia, Y. Guinet, L. Paccou, A. Hedoux, Freeze drying of pharmaceuticals and biologicals, Poster, Freeze Drying of Pharmaceuticals and Biologicals, Garmisch-Partenkirchen, Allemagne, Sep 2018 [LillOA]
  2. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of pharmaceutical materials within mesoporous silica matrices, Communication dans un congrès sans actes, 1st International Conference on Contemporary Pharmacy Challenges: 1st International Conference on Contemporary Pharmacy Challenges:, Wisla, Pologne, Sep 2018 [LillOA]
  3. B. Malfait, N. T. Correia, A. Mussi, Y. Guinet, A. Hedoux, Confinement of APIs inside porous silicate matrices by milling: analysis of the physical state and stability of confined APIs, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Grenade, Espagne, Mar 2018 [LillOA]
  4. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of pharmaceutical materials within mesoporous silica matrices, Communication dans un congrès sans actes, 1st International Conference on Contemporary Pharmacy Challenges (1 ICCPC) Amorphous Pharmaceuticals and Biopharmaceuticals, Wisla, Pologne, Sep 2018 [LillOA]
  5. M. Latreche, J. willart, A. Hedoux, Efficient solid state transformation protocol to determine the solubility of drugs into polymers, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  6. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J. Willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  7. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Mechanism of protein stabilization analyzed from in-situ Raman investigations during freeze-drying procedures, Conférence invitée, Freeze-drying of pharmaceuticals & biologicals, Garmisch-Partenkirchen, Allemagne, Sep 2018 [LillOA]
  8. T. Starciuc, A. Hedoux, Y. Guinet, L. Paccou, Mechanisms of protein denaturation and stabilization analyzed in-situ during the freeze-drying process by micro-Raman spectroscopy, Conférence invitée, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Juil 2017 [LillOA]
  9. J. Junthip, N. Tabary, B. Martel, N. Blanchemain, F. Chai, M. Maton, C. Neut, A. Hedoux, D. Landy, Multilayer assembly of oppositely charged cyclodextrin polymers on textile for controlled drug delivery, Communication dans un congrès sans actes, Pure and Applied Chemistry International Conference (PACCON), Bangkok, Thaïlande, Fév 2016 [LillOA]
  10. J. Junthip, N. Tabary, B. Martel, N. Blanchemain, F. Chai, A. Hedoux, D. Landy, L. Leclercq, Dual cyclodextrin polyelectrolyte multilayer coatings on textile for controlled drug delivery, Communication dans un congrès sans actes, EuroCD2015, Lille, France, Oct 2015 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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