Emeline Dudognon

Assistant professor

Bâtiment P5 - 213
Unité Matériaux et Transformations
Bât. P5
Université Lille1
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 69 90
Fax: +33 (0)3 20 43 40 84
Email: emeline.dudognon@univ-lille1.fr

Research team: Matériaux moléculaires et thérapeutiques

Research

* Crystalline/glassy state duality : phases transformations and low temperatures nucleation * Forced pharmaceutical materials: amorphisation, polymorphic transformations and obtaining by mecanosynthesis of out of equilibrium molecular alloys * Molecular mobility of glass forming liquids in the glass transition range

Teaching

Teaching at undergraduate level (fluids mecanic, electrokinetic,…)

Current PhD thesis

• Jeanne Annick BAMA, . Thesis started in 2017. Other co-advisor: Frédéric Affouard.

Defended PhD thesis

• Aurélien Mahieu, New methods to determine polymer / drug solubility diagrams. Thesis defended in 2013. Other co-advisor: Jean-François Willart. Present position: CDI/ Société ADOCIS "Rédacteur Technique Crédit Impôt Recherche (CIR)" à Angers au 1er Janvier 2015.
• Nicolas Dujardin, Solid State Amorphization of Glucose and Control of the Mutarotation. Thesis defended in 2009. Other co-advisor: Jean-François Willart.

Recent communications and seminars

24 oral presentation(s), including 11 invited. 9 poster(s). Detailled list.

Book contributions

1. E. Dudognon, S. Qi, in Disordered Pharmaceutical Materials [ed M. Descamps], Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, pp. 201-239 (2016) [doi: 10.1002/9783527652693.ch8]

Recent publications in international research journals

• 2017
  23. P. Martinetto, P. Bordet, M. Descamps, E. Dudognon, W. Pagnoux, J. F. Willart, Structural Transformations of d -Mannitol Induced by in Situ Milling Using Real Time Powder Synchrotron Radiation Diffraction, Crystal Growth & Design 17 6111-6122 (2017) [doi: 10.1021/acs.cgd.7b01283]
  22. J. F. Willart, E. Dudognon, A. Mahieu, M. Eddleston, W. Jones, M. Descamps, The role of cracks in the crystal nucleation process of amorphous griseofulvin, The European Physical Journal Special Topics 226 837-847 (2017) [doi: 10.1140/epjst/e2016-60358-y]
  21. A. Benazzouz, E. Dudognon, N. T. Correia, V. Molinier, J. M. Aubry, M. Descamps, Interactions underpinning the plasticization of a polymer matrix: a dynamic and structural analysis of DMP-plasticized cellulose acetate, Cellulose 24 487-503 (2017) [doi: 10.1007/s10570-016-1148-y]
• 2016
  20. B. Schammé, N. Couvrat, P. Malpeli, E. Dudognon, L. Delbreilh, V. Dupray, . Dargent, G. Coquerel, Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol, International Journal of Pharmaceutics 499 67-73 (2016) [doi: 10.1016/j.ijpharm.2015.12.032]
  19. P. Bordet, A. Bytchkov, M. Descamps, E. Dudognon, E. Elkaïm, P. Martinetto, W. Pagnoux, A. Poulain, J. F. Willart, Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis, Crystal Growth & Design 16 4547-4558 (2016) [doi: 10.1021/acs.cgd.6b00660]
• 2014
  18. M. Descamps, E. Dudognon, Crystallization from the Amorphous State: Nucleation–Growth Decoupling, Polymorphism Interplay, and the Role of Interfaces, Journal of Pharmaceutical Sciences 103 2615-2628 (2014) [doi: 10.1002/jps.24016]
• 2013
  17. N. Dujardin, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B 117 1437-1443 (2013) [doi: 10.1021/jp3069267]
  16. A. Mahieu, J. F. Willart, E. Dudognon, M. D. Eddleston, W. Jones, F. Danède, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102 462-468 (2013) [doi: 10.1002/jps.23349]
  15. A. Mahieu, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics 10 560-566 (2013) [doi: 10.1021/mp3002254]
  14. E. Dudognon, N. T. Correia, F. Danède, M. Descamps, Solid-Solid Transformation in Racemic Ibuprofen, Pharmaceutical Research 30 81-89 (2013) [doi: 10.1007/s11095-012-0851-0]
• 2011
  13. A. Hédoux, Y. Guinet, P. Derollez, E. Dudognon, N. T. Correia, Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II, International Journal of Pharmaceutics 421 45-52 (2011) [doi: 10.1016/j.ijpharm.2011.09.015]
  12. N. Tabary, A. Mahieu, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, M. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate Research 346 2193-2199 (2011) [doi: 10.1016/j.carres.2011.07.010]
  11. N. Dujardin, E. Dudognon, J. F. Willart, A. Hédoux, Y. Guinet, L. Paccou, M. Descamps, , Solid state mutarotation of glucose, J. Phys. Chem. B 115 1698-1705 (2011) [doi: 10.1021/jp109382j]
• 2010
  10. J. F. Willart, N. Dujardin, E. Dudognon, F. Danède, M. Descamps, Amorphization of sugar hydrates upon milling, Carbohydrate Research 345 1613 (2010) [doi: 10.1016/j.carres.2010.04.014]
  9. P. Derollez, E. Dudognon, F. Affouard, F. Danède, N. Correia, M. Descamps, Ab initio structure determination of phase II of racemic ibuprofen by X-ray powder diffraction, Acta Crystallographica Section B 66 76-80 (2010) [doi: 10.1107/S0108768109047363]
  8. N. Dujardin, J. F. Willart, E. Dudognon, F. Danède, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99 1476 - 1483 (2010) [doi: 10.1002/jps.21900]
• 2008
  7. E. Dudognon, F. Danède, M. Descamps, N. Correia, Evidence for a new crystalline phase of racemic ibuprofen, Pharmaceutical Research 25 2853 (2008) [doi: 10.1007/s11095-008-9655-7]
  6. N. Dujardin, J. F. Willart, E. Dudognon, A. Hédoux, Y. Guinet, L. Paccou, B. Chazallon, M. Descamps, Solid state vitrification of crystalline a and b-D-glucose by mechanical milling, Solid State Communications 148 78-82 (2008) [doi: 10.1016/j.ssc.2008.07.002]
• 2007
  5. M. Descamps, J. F. Willart, E. Dudognon, V. Caron, Transformation of pharmaceutical compounds upon milling and comilling: The role of Tg, Journal of Pharmaceutical Sciences 96 1398-1407 (2007) [doi: 10.1002/jps.20939]
• 2006
  4. M. Descamps, J. F. Willart, E. Dudognon, Non Equilibrium Transformations of Molecular Compounds Induced Mechanically, AIP Conference Proceedings 832 56 (2006) [doi: 10.1063/1.2204463]
  3. M. Descamps, J. F. Willart, E. Dudognon, R. Lefort, S. Desprez, V. Caron, Phase transformations induced by grinding: What is revealed by molecular materials, Materials Research Society Symposium Proceedings 979E 116-131, 0979-HH06-06 (2006)
  2. E. Dudognon, J. F. Willart, V. Caron, F. Capet, T. Larsson, M. Descamps, Formation of budesonide/a-lactose glass solutions by ball-milling, Solid State Communications 138 68-71 (2006) [doi: 10.1016/j.ssc.2006.02.007]
  1. J. F. Willart, E. Dudognon, N. Descamps, T. Larsson, M. Descamps, Lactose-based molecular alloys obtained by solid state vitrification, Journal of Non-Crystalline Solids 352 4475-4479 (2006) [doi: 10.1016/j.jnoncrysol.2006.01.142]